Document Detail


VGLUT1 mRNA and protein expression in the visual system of prosimian galagos (Otolemur garnetti).
MedLine Citation:
PMID:  22912561     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The presynaptic storage and release of glutamate, an excitatory neurotransmitter, is modulated by a family of transport proteins known as vesicular glutamate transporters. Vesicular glutamate transporter 1 (VGLUT1) is widely distributed in the central nervous system of most mammalian and nonmammalian species, and regulates the uptake of glutamate into synaptic vesicles as well as the transport of filled glutamatergic vesicles to the terminal membrane during excitatory transmission. In rodents, VGLUT1 mRNA is primarily found in the neocortex, cerebellum, and hippocampus, and the VGLUT1 transport protein is involved in intercortical and corticothalamic projections that remain distinct from projections involving other VGLUT isoforms. With the exception of a few thalamic sensory nuclei, VGLUT1 mRNA is absent from subcortical areas and does not colocalize with other VGLUT mRNAs. VGLUT1 is similarly restricted to a few thalamic association nuclei and does not colocalize with other VGLUT proteins. However, recent work in primates has shown that VGLUT1 mRNA is also found in several subcortical nuclei as well as cortical areas, and that VGLUT1 may overlap with other VGLUT isoforms in glutamatergic projections. In order to expand current knowledge of VGLUT1 distributions in primates and gain insight on glutamatergic transmission in the visual system of primate species, we examined VGLUT1 mRNA and protein distributions in the lateral geniculate nucleus, pulvinar complex, superior colliculus, V1, V2, and the middle temporal area (MT) of prosimian galagos. We found that, similar to other studies in primates, VGLUT1 mRNA and protein are widely distributed in both subcortical and cortical areas. However, glutamatergic projections involving VGLUT1 are largely limited to intrinsic connections within subcortical and cortical areas, as well as the expected intercortical and corticothalamic projections. Additionally, VGLUT1 expression in galagos allowed us to identify laminar subdivisions of the superior colliculus, V1, V2, and MT.
Authors:
Pooja Balaram; Troy A Hackett; Jon H Kaas
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Eye and brain     Volume:  2011     ISSN:  1179-2744     ISO Abbreviation:  Eye Brain     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101587774     Medline TA:  Eye Brain     Country:  -    
Other Details:
Languages:  ENG     Pagination:  81-98     Citation Subset:  -    
Affiliation:
Department of Psychology, Vanderbilt University, Nashville, TN, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cerebral lipiodol embolism after transarterial chemoembolization for hepatic carcinoma: a case repor...
Next Document:  Systematic dissection of roles for chromatin regulators in a yeast stress response.