Document Detail

VEGF plasma levels in non-ruptured intracranial aneurysms.
MedLine Citation:
PMID:  16133453     Owner:  NLM     Status:  MEDLINE    
Aneurysm growth appears to be associated with an increased risk of rupture. Therefore, it may be of interest to identify mechanisms contributing to aneurysm growth. Angiogenic factors, particularly vascular endothelial growth factor (VEGF), appear to play an important role in the pathogenesis and growth of cerebrovascular malformations. We aimed to study systemic VEGF levels as a potential systemic marker in patients with non-ruptured intracranial aneurysms compared with healthy controls. Mean VEGF plasma concentrations were found to be increased in patients with non-ruptured intracranial aneurysms compared with healthy controls (85.2 pg/ml versus 44.1 pg/ml). This difference did not reach significance in the analyzed study cohort (p=0.05) but only when the analysis was restricted to male patients (p=0.04). Female patients and controls demonstrated significantly increased VEGF plasma levels only on correlation with age but not with the presence of aneurysms. Neither the presence of multiple aneurysms nor aneurysm location were correlated with VEGF levels. Although overall VEGF plasma difference was not statistically significant, we found significantly increased levels in male patients. Furthermore, we identified a distinct group of female patients with intracranial aneurysms who presented excessively increased VEGF plasma levels to an amount that was not observed in the controls. Further studies may clarify the relationship of aneurysm growth and VEGF.
I Erol Sandalcioglu; Doreen Wende; Angelika Eggert; Jens P Regel; Dietmar Stolke; Helmut Wiedemayer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-25
Journal Detail:
Title:  Neurosurgical review     Volume:  29     ISSN:  0344-5607     ISO Abbreviation:  Neurosurg Rev     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7908181     Medline TA:  Neurosurg Rev     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  26-9     Citation Subset:  IM    
Department of Neurosurgery, University Clinic of Essen, Hufelandstrasse 55, 45122 Essen, Germany.
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MeSH Terms
Age Factors
Aneurysm, Ruptured / blood,  etiology,  pathology
Biological Markers
Cohort Studies
Data Interpretation, Statistical
Intracranial Aneurysm / blood*,  etiology,  pathology
Middle Aged
Sex Factors
Vascular Endothelial Growth Factor A / blood*,  physiology
Reg. No./Substance:
0/Biological Markers; 0/Vascular Endothelial Growth Factor A

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