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VEGF pathway inhibition by anticancer agent sunitinib and susceptibility to atherosclerosis plaque disruption.
MedLine Citation:
PMID:  20676744     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Patients treated with anti-VEGF agents are at increased risk for arterial thrombo-embolic events (ATEs). However, the pathophysiology of such acute vascular complications remains unclear. We report on a case of bowel infarction in a renal cancer patient treated with the anti-VEGF agent sunitinib. An abdominal CT-scan evidenced the rupture of an atherosclerotic plaque located at the emergence of the superior mesenteric artery. In view of this report, we suggest that evaluation of the risk of ATE in patients receiving anti-VEGF agents should include not only age and past history of ATE as suggested by previous studies, but also assessment of atherosclerotic lesions on CT-scan.
Authors:
Stanislas Ropert; Olivier Vignaux; Olivier Mir; François Goldwasser
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Publication Detail:
Type:  Journal Article     Date:  2010-07-30
Journal Detail:
Title:  Investigational new drugs     Volume:  29     ISSN:  1573-0646     ISO Abbreviation:  Invest New Drugs     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-09-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309330     Medline TA:  Invest New Drugs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1497-9     Citation Subset:  IM    
Affiliation:
Centre for Research on Angiogenesis Inhibitors (CERIA), Department of Medical Oncology, AP-HP, Cochin Teaching Hospital, Université Paris Descartes, 27, rue du faubourg saint Jacques, F75014, Paris, France.
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