Document Detail

The VEGF pathway in cancer and disease: responses, resistance, and the path forward.
MedLine Citation:
PMID:  23209176     Owner:  NLM     Status:  In-Data-Review    
Antiangiogenesis was proposed as a novel target for the treatment of cancer 40 years ago. Since the original hypothesis put forward by Judah Folkman in 1971, factors that mediate angiogenesis, their cellular targets, many of the pathways they signal, and inhibitors of the cytokines and receptors have been identified. Vascular endothelial growth factor (VEGF) is the most prominent among the angiogenic cytokines and is believed to play a central role in the process of neovascularization, both in cancer as well as other inflammatory diseases. This article reviews the biology of VEGF and its receptors, the use of anti-VEGF approaches in clinical disease, the toxicity of these therapies, and the resistance mechanisms that have limited the activity of these agents when used as monotherapy.
Mark W Kieran; Raghu Kalluri; Yoon-Jae Cho
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Publication Detail:
Type:  Journal Article     Date:  2012-12-01
Journal Detail:
Title:  Cold Spring Harbor perspectives in medicine     Volume:  2     ISSN:  2157-1422     ISO Abbreviation:  Cold Spring Harb Perspect Med     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101571139     Medline TA:  Cold Spring Harb Perspect Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Department of Pediatric Medical Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
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