| VEGF and imaging of vessels in rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 12110128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiogenesis is a prominent feature of rheumatoid synovitis. Formation of new blood vessels permits a supply of nutrients and oxygen to the augmented inflammatory cell mass and so contributes to perpetuation of joint disease. Vascular endothelial growth factor (VEGF) is a potent endothelial cell-specific growth factor that is upregulated by proinflammatory cytokines and by hypoxia. Serum VEGF concentrations are elevated in rheumatoid arthritis (RA) and correlate with disease activity. Furthermore, serum VEGF measured at first presentation in RA is highly significantly correlated with radiographic progression of disease over the subsequent year. Power Doppler ultrasonography is a sensitive method for demonstrating the presence of blood flow in small vessels and there is a very close relation between the presence or absence of vascular flow signal on power Doppler imaging and the rate of early synovial enhancement on dynamic gadolinium-enhanced magnetic resonance imaging (MRI) of joints with RA. Images obtained by both dynamic enhanced MRI and power Doppler ultrasonography correlate with vascularity of synovial tissue as assessed histologically. In early RA, there is a striking association between joint erosions assessed on high-resolution ultrasonography and vascular signal in power Doppler mode. Collectively, these findings implicate vascular pannus in the erosive phase of disease and strongly suggest that proangiogenic molecules such as VEGF are targets for novel therapies in RA. Animal model data supports this concept. It seems likely that serological and imaging measures of vascularity in RA will become useful tools in the assessment of disease activity and response to therapy. |
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Authors:
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Peter C Taylor |
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Publication Detail:
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Type: Journal Article; Review Date: 2002-05-09 |
Journal Detail:
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Title: Arthritis research Volume: 4 Suppl 3 ISSN: 1465-9905 ISO Abbreviation: Arthritis Res. Publication Date: 2002 |
Date Detail:
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Created Date: 2002-07-11 Completed Date: 2003-05-22 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 100913255 Medline TA: Arthritis Res Country: England |
Other Details:
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Languages: eng Pagination: S99-107 Citation Subset: IM |
Affiliation:
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The Kennedy Institute Division, Imperial College School of Medicine, London, UK. peter.c.taylor@ic.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arthritis, Rheumatoid
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pathology*,
ultrasonography* Blood Vessels / pathology, ultrasonography Endothelial Growth Factors / blood* Humans Intercellular Signaling Peptides and Proteins / blood* Lymphokines / blood* Magnetic Resonance Imaging Synovial Membrane / blood supply*, pathology, ultrasonography Ultrasonography, Doppler Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors |
| Chemical | |
Reg. No./Substance:
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0/Endothelial Growth Factors; 0/Intercellular Signaling Peptides and Proteins; 0/Lymphokines; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors |
| Comments/Corrections | |
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