Document Detail

VEGF-A, VEGFR-1, VEGFR-2 and Tie2 levels in plasma of premature infants: relationship to retinopathy of prematurity.
MedLine Citation:
PMID:  18408080     Owner:  NLM     Status:  MEDLINE    
AIM: To study prospectively the plasma levels of vascular endothelial growth factor (VEGF-A), its soluble receptors sVEGFR-1, sVEGFR-2 and soluble Tie2 in premature infants. To identify their changes related to the onset of retinopathy of prematurity (ROP). METHODS: Blood samples of 63 preterm infants born at a postmenstrual age (PMA) of 23-32 weeks were obtained between 5 days and 15 weeks after birth. 42 infants had no ROP, two had stage 1, nine stage 2 and 10 stage 3. Of these, four infants were treated with retinal photocoagulation. VEGF-A, sVEGFR-1, sVEGFR-2, and sTie2 were measured in the plasma with a sandwich enzyme immunoassay using factor-specific monoclonal mouse antibodies. The time course of concentrations plotted by kernel smoothing in infants with and without ROP were compared and a paired subgroup with analysis of variance was analysed. RESULTS: ROP patients had raised plasma levels of sVEGFR-2 and sTie2 compared with premature infants without ROP. VEGF-A and sVEGFR-1 levels were similar in both groups. Analysis of a subgroup with pairs of measurements, one before 32 weeks and one after 36 weeks, showed a significant increase in sTie2 after 36 weeks of PMA independent of ROP (p = 0.03). CONCLUSION: This is the first study to measure plasma levels of angiogenic factors in ROP. Similar VEGF-A plasma levels in infants with and without ROP suggest that pathogenic retinal angiogenesis in ROP is mainly driven by local VEGF-A synthesis. Elevated plasma levels in active ROP were observed for sVEGFR-2 and sTie2. These increases have yet to be confirmed as predictive values for ROP.
C Pieh; H Agostini; C Buschbeck; M Krüger; J Schulte-Mönting; U Zirrgiebel; J Drevs; W A Lagrèze
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-04-11
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  92     ISSN:  1468-2079     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-28     Completed Date:  2008-05-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  689-93     Citation Subset:  IM    
Department of Ophthalmology, University Hospital Freiburg, Freiburg, Germany.
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MeSH Terms
Analysis of Variance
Disease Progression
Gestational Age
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Prospective Studies
Receptor, TIE-2 / blood*
Retinopathy of Prematurity / blood*
Vascular Endothelial Growth Factor A / blood*
Vascular Endothelial Growth Factor Receptor-1 / blood*
Vascular Endothelial Growth Factor Receptor-2 / blood*
Reg. No./Substance:
0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; EC, TIE-2; EC Endothelial Growth Factor Receptor-1; EC Endothelial Growth Factor Receptor-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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