Document Detail


[VEGF antibodies as therapy for retinopathy of prematurity].
MedLine Citation:
PMID:  20845249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Retinopathy of prematurity (ROP) is one of the three leading causes of legal blindness in childhood in the developed countries. Improved neonatal care has resulted in the increased survival of extremely immature infants at high risk to develop ROP. Current treatment for ROP with laser may prevent blindness by causing involution of pathological vessels and thus inhibit the development of retinal detachment. But this coagulation of the avascular retina is a destructive therapy and does not otherwise ameliorate retinal development. Recent reports have described vascular endothelial growth factor antibodies as therapy for ROP. This article reports our own experience with this new therapy and gives an overview of the recent literature.
Authors:
I M Oberacher-Velten; H Helbig
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Publication Detail:
Type:  English Abstract; Journal Article; Review     Date:  2010-09-15
Journal Detail:
Title:  Klinische Monatsblätter für Augenheilkunde     Volume:  227     ISSN:  1439-3999     ISO Abbreviation:  Klin Monbl Augenheilkd     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2011-02-18     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  0014133     Medline TA:  Klin Monbl Augenheilkd     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  694-700     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Affiliation:
Klinik und Poliklinik für Augenheilkunde, Klinikum der Universität Regensburg. isabel.velten@klinik.uniregensburg.de
Vernacular Title:
VEGF-Antikörper in der Therapie der Frühgeborenenretinopathie.
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MeSH Terms
Descriptor/Qualifier:
Angiogenesis Inhibitors / administration & dosage*,  adverse effects
Antibodies, Monoclonal / administration & dosage*,  adverse effects
Antibodies, Monoclonal, Humanized
Combined Modality Therapy
Diseases in Twins / classification,  diagnosis,  drug therapy,  physiopathology
Female
Humans
Infant, Extremely Low Birth Weight
Infant, Newborn
Intravitreal Injections
Laser Coagulation
Male
Off-Label Use
Retinopathy of Prematurity / classification,  diagnosis,  drug therapy*,  physiopathology
Vascular Endothelial Growth Factor A / antagonists & inhibitors*,  physiology
Chemical
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 2S9ZZM9Q9V/bevacizumab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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