Document Detail

VBR in schizophrenia: relationship to family history of psychosis and season of birth.
MedLine Citation:
PMID:  8827854     Owner:  NLM     Status:  MEDLINE    
Ventricular enlargement has been consistently demonstrated in schizophrenia using both CT and MRI. Despite this, the structural changes that underlie increased ventricle-brain ratio (VBR) and its relationship to environmental factors (intrauterine viral exposure, obstetric complications, etc.) and family history of schizophrenia remain poorly defined. Increased VBR has been shown in some studies to correlate with an absence of family history of schizophrenia and with Winter-Spring birth. In an attempt to obtain a clearer picture of the contribution of environmental and genetic factors to VBR, we studied 54 patients with DSM III-R schizophrenia. VBR was determined from head CT scans via computerized planimetry. Family history of psychosis and non-psychotic mood disorder was determined with the family informant method. Season of birth was encoded in several ways, including season, trimester and dichotomously. Patients without a family history of psychosis had significantly larger VBR than patients with such a history; family history of mood disorder was not related to VBR. Season of birth was not predictive of VBR. Family history of psychosis and season of birth were not related to each other. These results are in line with prior work demonstrating an association between increased VBR and sporadic (non-familial) schizophrenia. We did not find a relationship between VBR and season of birth, which suggests that risk of perinatal viral exposure and other seasonal environmental factors may not account for the ventricular enlargement in non-familial schizophrenia observed in our sample.
J R DeQuardo; M Goldman; R Tandon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Schizophrenia research     Volume:  20     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-26     Completed Date:  1996-12-26     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  275-85     Citation Subset:  IM    
Schizophrenia Program, University of Michigan Medical Center, Ann Arbor 48109-0116, USA.
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MeSH Terms
Brain / pathology*
Cerebral Ventricles / pathology*
Magnetic Resonance Imaging*
Psychiatric Status Rating Scales
Risk Factors
Schizophrenia / diagnosis,  epidemiology,  genetics*
Schizophrenic Psychology
Tomography, X-Ray Computed*
Grant Support
Erratum In:
Schizophr Res 1997 May 24;25(2):167

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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