| VAMP2 is expressed in muscle satellite cells and up-regulated during muscle regeneration. | |
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MedLine Citation:
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PMID: 17468895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Membrane trafficking is one of the most important mechanisms involved in the establishment and maintenance of the forms and functions of the cell. However, it is poorly understood in skeletal muscle cells. In this study, we have focused on vesicle-associated membrane proteins (VAMPs), which are components of the vesicle docking and fusion complex, and have performed immunostaining to investigate the expression of VAMPs in rat skeletal muscle tissue. We have found that VAMP2, but not VAMP1 or VAMP3, is expressed in satellite cells. VAMP2 is also expressed in myofibers in the soleus muscle and nerve endings. This is consistent with previous studies in which VAMP2 has been shown to regulate GLUT4 trafficking in slow-twitch myofibers in soleus muscle and neurotransmitter release in nerve endings. As satellite cells are quiescent myogenic cells, the expression of VAMP2 has further been examined in regenerating muscles after injury by the snake venom, cardiotoxin; we have observed enhanced expression of VAMP2 in immature myotubes with a peak at 3 days after injury. Our findings suggest that VAMP2 plays roles in quiescent satellite cells and is involved in muscle regeneration. The nature of the material transported in the VAMP2-bearing vesicles in satellite cells and myotubes is still under investigation. |
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Authors:
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Yuki Tajika; Mahito Sato; Tohru Murakami; Kuniaki Takata; Hiroshi Yorifuji |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-02-14 |
Journal Detail:
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Title: Cell and tissue research Volume: 328 ISSN: 0302-766X ISO Abbreviation: Cell Tissue Res. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-04-30 Completed Date: 2007-09-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: Germany |
Other Details:
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Languages: eng Pagination: 573-81 Citation Subset: IM |
Affiliation:
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Department of Neuromuscular and Developmental Anatomy, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Male Muscle Fibers, Skeletal / metabolism Muscle, Skeletal / physiology* Rats Rats, Wistar Regeneration / genetics* Satellite Cells, Skeletal Muscle / metabolism* Up-Regulation* Vesicle-Associated Membrane Protein 1 / metabolism Vesicle-Associated Membrane Protein 2 / genetics*, metabolism Vesicle-Associated Membrane Protein 3 / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Vamp2 protein, rat; 0/Vesicle-Associated Membrane Protein 1; 0/Vesicle-Associated Membrane Protein 2; 0/Vesicle-Associated Membrane Protein 3; 0/vesicle-associated membrane protein 1, rat; 0/vesicle-associated membrane protein 3, rat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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