| The V227A polymorphism at the PPARA locus is associated with serum lipid concentrations and modulates the association between dietary polyunsaturated fatty acid intake and serum high density lipoprotein concentrations in Chinese women. | |
| | |
MedLine Citation:
|
PMID: 16288935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Peroxisome proliferators activated receptor alpha (PPARalpha) regulates the transcription of several proteins involved in human lipoprotein metabolism. We screened the PPARA locus for polymorphisms in 20 unrelated subjects from each of three ethnic groups (Chinese, Malays and Asian Indians). Only the V227A polymorphism was observed. We genotyped 4248 subjects (2899 Chinese, 761 Malay and 588 Asian Indians) and found allele frequencies for the A227 allele of 0.04 in Chinese, 0.006 in Malays and 0.003 in Asian Indians. We examined the associations between this polymorphism and serum lipid concentrations in Chinese. In women, but not in men, the presence of the A227 allele was associated with lower serum concentrations of total cholesterol [5.38mmol/l (95%CI: 5.22-5.54) versus 5.21mmol/l (95%CI: 4.99-5.43), p=0.047] and triglycerides [1.19mmol/l (95%CI: 1.10-1.28) versus 1.09mmol/l (95%CI: 0.98-1.21), p=0.048]. We also found that the V227A polymorphism modulates the association between dietary polyunsaturated fatty acid intake and serum high density lipoprotein concentration (p-value for interaction=0.049). Our findings implicate PPARalpha in the lipid lowering associated with diets high in PUFA and suggests that genetic variation at the PPARA locus may determine the lipid response to changes in PUFA intake. |
| | |
Authors:
|
Edmund Chan; Chuen Seng Tan; Mabel Deurenberg-Yap; Kee Seng Chia; Suok Kai Chew; E Shyong Tai |
Related Documents
:
|
184835 - Radioimmunoassay of apolipoprotein a-i of rat serum. 9532235 - Apolipoprotein and lipid abnormalities in chronic liver failure. 3973025 - Effect of heparin-induced lipolysis on the distribution of apolipoprotein e among lipop... 11257255 - Apoprotein e genotype and the response of serum cholesterol to dietary fat, cholesterol... 20418335 - Mouse urinary biomarkers provide signatures of maturation, diet, stress level, and diur... 11726265 - Dietary practices, attitudes, and physiological status of collegiate freshman football ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-11-09 |
Journal Detail:
|
Title: Atherosclerosis Volume: 187 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 2006 Aug |
Date Detail:
|
Created Date: 2006-07-04 Completed Date: 2006-12-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
|
Languages: eng Pagination: 309-15 Citation Subset: IM |
Affiliation:
|
Department of Endocrinology, Singapore General Hospital, Block 6 level 6, Room B35, Outram Road, Singapore 169608, Republic of Singapore. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Asian Continental Ancestry Group / genetics* Cholesterol / blood Dietary Fats / administration & dosage* Fatty Acids, Unsaturated / administration & dosage* Female Food Habits Genotype Health Surveys Humans Life Style Lipoproteins, HDL / blood* Male Middle Aged PPAR alpha / genetics* Polymorphism, Genetic Questionnaires Sex Characteristics |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Fats; 0/Fatty Acids, Unsaturated; 0/Lipoproteins, HDL; 0/PPAR alpha; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Circulating endothelial progenitor cells from healthy smokers exhibit impaired functional activities...
Next Document: Age related differences in the immune response to vaccination and infection with Mycoplasma gallisep...