Document Detail

A V-shaped ligand 1,3-bis(1-methylbenzimidazol-2-yl)-2-oxapropane and its Cu(II) complex: Synthesis, crystal structure, antioxidation and DNA-binding properties.
MedLine Citation:
PMID:  21978475     Owner:  NLM     Status:  Publisher    
A six-coordinate copper(II) complex with the ligand 1,3-bis(1-methylbenzimidazol-2-yl)-2-oxopropane (Meobb), with composition [Cu(Meobb)(2)](NO(3))(2)·2CH(3)OH, has been synthesized and characterized by elemental analysis, electrical conductivities, IR, UV-Vis spectral measurements. A study of the electro-chemistry of the copper(II) complex was carried out by using cyclic voltammetry. The molecular structures of the ligand Meobb and the Cu(II) complex were determined by X-ray crystal diffraction. The DNA-binding modes of the ligand and the complex were investigated by electronic absorption titration, ethidium bromide-DNA displacement experiments and viscosity measurements. The experimental evidence indicated the compounds interact with calf thymus DNA through intercalation. Additionally, the Cu(II) complex exhibited potential antioxidant properties in in vitro studies.
Huilu Wu; Fan Kou; Fei Jia; Bin Liu; Jingkun Yuan; Ying Bai
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-22
Journal Detail:
Title:  Journal of photochemistry and photobiology. B, Biology     Volume:  -     ISSN:  1873-2682     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-10-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804966     Medline TA:  J Photochem Photobiol B     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, PR China.
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