Document Detail


The V-ATPase inhibitors concanamycin A and bafilomycin A lead to Golgi swelling in tobacco BY-2 cells.
MedLine Citation:
PMID:  15614486     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Concanamycin A and bafilomycin A are well-known inhibitors of V-ATPase activity. It is known that they interfere with intracellular protein trafficking in both animal and plant cells, but a cellular target for their action in plant cells has not been defined. Here we show that treatment with these inhibitors leads to a massive vacuolation of the Golgi apparatus. The effect is similar, but not identical, to that previously described for the Na+/K+ ionophores and is reversible after washing.
Authors:
D G Robinson; S Albrecht; Y Moriysu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-12-22
Journal Detail:
Title:  Protoplasma     Volume:  224     ISSN:  0033-183X     ISO Abbreviation:  Protoplasma     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-22     Completed Date:  2005-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9806853     Medline TA:  Protoplasma     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  255-60     Citation Subset:  IM    
Affiliation:
Department Cell Biology, Heidelberg Institute for Plant Sciences, University of Heidelberg, Heidelberg, Federal Republic of Germany. david.robinson@urz.uni-heidelberg.de
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MeSH Terms
Descriptor/Qualifier:
Cells, Cultured
Enzyme Inhibitors / pharmacology
Golgi Apparatus / drug effects*,  enzymology,  ultrastructure
Intracellular Membranes / drug effects,  enzymology,  ultrastructure
Macrolides / pharmacology*
Microscopy, Electron, Transmission
Protein Transport / drug effects,  physiology
Tobacco / drug effects*,  enzymology,  ultrastructure
Vacuolar Proton-Translocating ATPases / antagonists & inhibitors*,  metabolism
Vacuoles / drug effects,  enzymology,  ultrastructure
Water-Electrolyte Balance / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Macrolides; 116764-51-3/bafilomycin A; 80890-47-7/concanamycin A; EC 3.6.1.-/Vacuolar Proton-Translocating ATPases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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