| The V-ATPase inhibitors concanamycin A and bafilomycin A lead to Golgi swelling in tobacco BY-2 cells. | |
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MedLine Citation:
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PMID: 15614486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Concanamycin A and bafilomycin A are well-known inhibitors of V-ATPase activity. It is known that they interfere with intracellular protein trafficking in both animal and plant cells, but a cellular target for their action in plant cells has not been defined. Here we show that treatment with these inhibitors leads to a massive vacuolation of the Golgi apparatus. The effect is similar, but not identical, to that previously described for the Na+/K+ ionophores and is reversible after washing. |
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Authors:
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D G Robinson; S Albrecht; Y Moriysu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-12-22 |
Journal Detail:
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Title: Protoplasma Volume: 224 ISSN: 0033-183X ISO Abbreviation: Protoplasma Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-22 Completed Date: 2005-07-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9806853 Medline TA: Protoplasma Country: Austria |
Other Details:
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Languages: eng Pagination: 255-60 Citation Subset: IM |
Affiliation:
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Department Cell Biology, Heidelberg Institute for Plant Sciences, University of Heidelberg, Heidelberg, Federal Republic of Germany. david.robinson@urz.uni-heidelberg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cells, Cultured Enzyme Inhibitors / pharmacology Golgi Apparatus / drug effects*, enzymology, ultrastructure Intracellular Membranes / drug effects, enzymology, ultrastructure Macrolides / pharmacology* Microscopy, Electron, Transmission Protein Transport / drug effects, physiology Tobacco / drug effects*, enzymology, ultrastructure Vacuolar Proton-Translocating ATPases / antagonists & inhibitors*, metabolism Vacuoles / drug effects, enzymology, ultrastructure Water-Electrolyte Balance / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Macrolides; 116764-51-3/bafilomycin A; 80890-47-7/concanamycin A; EC 3.6.1.-/Vacuolar Proton-Translocating ATPases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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