Document Detail

Uveitis, an under-recognized adverse effect of pamidronate. Case report and literature review.
MedLine Citation:
PMID:  10963085     Owner:  NLM     Status:  MEDLINE    
Ophthalmologic adverse effects of bisphosphonate therapy are infrequent and of unclear pathogenesis. The most common has been anterior uveitis, of which 18 cases have been reported. Onset was within 24 to 48 hours after infusion initiation, and both eyes were affected in most patients. The outcome was favorable within a few days after bisphosphonate discontinuation and topical glucocorticoid therapy, although rechallenge was frequently followed by a recurrence. Bisphosphonates are being used successfully in an increasingly broad range of disorders. We report a case of pamidronate-induced anterior uveitis and present a review of the relevant literature.
J Rey; V Daumen-Legré; T Pham; P Bernard; L Dahan; P C Acquaviva; P Lafforgue
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Joint, bone, spine : revue du rhumatisme     Volume:  67     ISSN:  1297-319X     ISO Abbreviation:  Joint Bone Spine     Publication Date:  2000  
Date Detail:
Created Date:  2000-12-04     Completed Date:  2000-12-22     Revised Date:  2006-10-11    
Medline Journal Info:
Nlm Unique ID:  100938016     Medline TA:  Joint Bone Spine     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  337-40     Citation Subset:  IM    
Rheumatology Department, La Timone Teaching Hospital, Marseilles, France.
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MeSH Terms
Anti-Inflammatory Agents / adverse effects*
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Dexamethasone / therapeutic use
Diclofenac / therapeutic use
Diphosphonates / adverse effects*
Glucocorticoids / therapeutic use
Middle Aged
Uveitis / chemically induced*,  drug therapy
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Diphosphonates; 0/Glucocorticoids; 15307-86-5/Diclofenac; 40391-99-9/pamidronate; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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