| Uveitis management: a multidisciplinary approach to assess systemic involvement and side effects of treatments. | |
| | |
MedLine Citation:
|
PMID: 12212355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Non-infectious uveitis is often associated with systemic diseases severe enough to require corticosteroids (CS) and immunosuppressive drugs, which have potential serious side effects. METHODS: 28 patients with non-infectious uveitis were referred by the ophthalmologist. RESULTS: A systemic disease was found in 17/28 patients (60%): sarcoidosis in 11, spondylarthropathy in 3, Behcet's disease in 2, Crohn's disease in 1 patient. Eighteen patients received CS, 21 patients received immunosuppressive drugs. Most side effects were due to CS treatment: Cushing's syndrome in 12, cataract in 11, glucose intolerance in 3, gastric ulcus in 1, hypertension in 1, osteoporosis in 17, avascular bone necrosis in 3 patients. Prophylaxis or treatment of corticosteroids induced osteoporosis consists in calcium, 500 mg/day and vitamin D 400 IU in most of them with in addition hormone replacement therapy (n = 8) or bisphosphonates (n = 13). CONCLUSION: Sixty percent of patients with severe uveitis had a systemic disease. CS were the most deleterious drugs in spite of bi- or tri-therapy with CS sparing immunosuppressive drugs. |
| | |
Authors:
|
A Peretz; M P Guillaume; L Casper-Velu |
Related Documents
:
|
18609475 - Ocular inflammatory signs observed in a cohort of spanish patients with behçet disease... 18849915 - Refractive errors and strabismus in asian patients with down syndrome. 4058855 - Uveitis with allergy to candidin. 12841565 - Genetic polymorphism of hla dr in a scottish population of patients with pars planitis. 6983765 - Fluid therapy for gastrointestinal, pancreatic, and hepatic disorders. 21511585 - Clinical and cytogenetic evaluation of three patients with swyer-james syndrome. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta clinica Belgica Volume: 57 ISSN: 0001-5512 ISO Abbreviation: Acta Clin Belg Publication Date: 2002 Jun-Jul |
Date Detail:
|
Created Date: 2002-09-05 Completed Date: 2002-10-11 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370306 Medline TA: Acta Clin Belg Country: Belgium |
Other Details:
|
Languages: eng Pagination: 142-7 Citation Subset: IM |
Affiliation:
|
Internal Medicine Department, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Belgique. aperetz@ulb.ac.be |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Cortex Hormones
/
therapeutic use* Adult Female Humans Immunosuppressive Agents / therapeutic use Male Patient Care Team* Severity of Illness Index Uveitis / etiology, therapy* Vitamin D / diagnostic use* |
| Chemical | |
Reg. No./Substance:
|
0/Adrenal Cortex Hormones; 0/Immunosuppressive Agents; 1406-16-2/Vitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical, biophysical and biochemical variables from African-heritage subjects with type 2 diabetes.
Next Document: Hurthle cell thyroid carcinoma: report of 13 cases