Document Detail

Uveal melanomas presenting during pregnancy and the investigation of oestrogen receptors in melanomas.
MedLine Citation:
PMID:  7126514     Owner:  NLM     Status:  MEDLINE    
We observed a young woman who showed growth of a choroidal melanoma over the course of 2 pregnancies, with subsequent enucleation of the eye. This is the first such documented case. In addition 4 other women with uveal malignant melanomas presented during pregnancy. This observed number of pregnancies (5) was greater than the expected number (2.1) among women of childbearing age who underwent enucleation with subsequent analysis in our pathology laboratory. However, this difference was not statistically significant. Further, more females 44 years of age or younger underwent enucleation for malignant melanoma than men of comparable age. Evaluation of these cases led us to propose that there is a subset of patients whose ocular melanomas are hormonally responsive. We therefore analysed uveal melanoma and choroidal tissue from 7 patients, including one of the pregnant women, for the presence of oestrogen receptors. No specific oestrogen binding was found. The possibilities that other hormones are involved or an immunological mechanism is operative are discussed.
J M Seddon; D T MacLaughlin; D M Albert; E S Gragoudas; M Ference
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  66     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  1982 Nov 
Date Detail:
Created Date:  1982-12-18     Completed Date:  1982-12-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  695-704     Citation Subset:  IM    
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MeSH Terms
Choroid Neoplasms / pathology
Fluorescein Angiography
Melanoma / analysis*,  pathology
Neoplasms, Hormone-Dependent / analysis*,  pathology
Pregnancy Complications, Neoplastic / analysis*,  pathology
Receptors, Estrogen / analysis*
Uveal Neoplasms / analysis*,  pathology
Grant Support
1 F32 EY05507-01/EY/NEI NIH HHS
Reg. No./Substance:
0/Receptors, Estrogen

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