Document Detail


Uveal malignant melanoma and von Recklinghausen's neurofibromatosis.
MedLine Citation:
PMID:  3135111     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A case of uveal malignant melanoma with extensive spread to the central nervous system occurring in a 63-year-old woman with peripheral-type von Recklinghausen's neurofibromatosis was studied by light microscopy. The tumor histologically consisted of large, loosely coherent epithelioid cells with abundant eosinophilic cytoplasm and large, irregular nuclei with prominent nucleoli. The tumor cells contained variable amounts of melanin pigment and exhibited positive immunohistochemical staining for S-100 protein and neuron-specific enolase. A review of the literature disclosed only ten previous cases of uveal malignant melanoma associated with von Recklinghausen's neurofibromatosis. A predominance of women and of the peripheral variant of von Recklinghausen's neurofibromatosis was noticed in the cases reported.
Authors:
C S Specht; T W Smith
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Cancer     Volume:  62     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-09-01     Completed Date:  1988-09-01     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  812-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Ophthalmic Pathology, Armed Forces, Institute of Pathology, Washington DC 20306-6000.
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Immunohistochemistry
Melanoma / pathology*
Middle Aged
Neoplasms, Multiple Primary*
Neurofibromatosis 1 / pathology*
Phosphopyruvate Hydratase / analysis
S100 Proteins / analysis
Uveal Neoplasms / pathology*
Chemical
Reg. No./Substance:
0/S100 Proteins; EC 4.2.1.11/Phosphopyruvate Hydratase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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