| Utilizing intraluminal pressure differences to predict esophageal bolus flow dynamics. | |
| | |
MedLine Citation:
|
PMID: 17855763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Successful esophageal emptying depends on the generation of a sustained intrabolus pressure (IBP) sufficient to overcome esophagogastric junction (EGJ) obstruction. Our aim was to develop a manometric analysis paradigm that describes the bolus driving pressure difference and the flow permissive time for esophageal bolus transit. Twenty normal subjects were studied with a 36-channel manometry assembly (1-cm spacing) during two 5- and one 10-ml barium swallows and concurrent fluoroscopy. Bolus domain pressure plots were generated by plotting bolus domain pressure (BDP) and EGJ relaxation pressure. BDP was defined as the pressure midway between the peristaltic ramp-up and the proximal margin of the EGJ. The flow permissive time was defined as the period where the BDP was > or = EGJ relaxation pressure. The mean BDP was 11.7 +/- 1.0 mmHg (SE), and the mean flow permissive time was 3.9 +/- 0.4 s for 5-ml swallows in normal controls. The mean BDP difference during flow was 4.0 +/- 1.0 mmHg. There was no significant difference in the fluoroscopic transit time and the flow permissive time calculated from the BDP plots (5 ml: fluoroscopy 3.4 +/- 0.2 s; BDP 3.9 +/- 0.4 s, P > 0.05). BDP plots provide a reliable measurement of IBP and its relationship with EGJ relaxation. The time available for flow can be readily delineated from this analysis, and the driving pressure responsible for flow can be accurately described and quantified. This may help predict abnormal bolus transit and the underlying mechanical properties of the EGJ. |
| | |
Authors:
|
Sudip K Ghosh; Peter J Kahrilas; Nilesh Lodhia; John E Pandolfino |
Related Documents
:
|
19808653 - Heightened colon motor activity measured by a wireless capsule in patients with constip... 15479603 - Physical principles of available adjustable gastric bands: how they work. 8668603 - Pathophysiology of heart failure: changing perceptions. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-09-13 |
Journal Detail:
|
Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 293 ISSN: 0193-1857 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2007 Nov |
Date Detail:
|
Created Date: 2007-11-06 Completed Date: 2007-12-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: G1023-8 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Northwestern University, Feinberg School of Medicine, Division of Gastroenterology, Chicago, IL 60611, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Deglutition / physiology* Esophagus / cytology, physiology* Fluoroscopy Gastrointestinal Motility / physiology* Humans Middle Aged Pressure Reference Values Stomach / cytology, physiology |
| Grant Support | |
ID/Acronym/Agency:
|
K23 DK062170-01/DK/NIDDK NIH HHS; R01 DC00646/DC/NIDCD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lipolysis and fatty acid metabolism in men and women during the postexercise recovery period.
Next Document: Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resectio...