Document Detail


Utilizing combination therapy in the treatment of Alzheimer's disease.
MedLine Citation:
PMID:  15853507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alzheimer's disease may not yet be curable, but it is treatable. Two classes of drugs with differing mechanisms of action have received Food and Drug Administration approval for the treatment of Alzheimer's disease: the cholinesterase inhibitors and the N-methyl-D-aspartate receptor antagonist memantine (Ebixa, Lundbeck; Namenda, Forest Laboratories). Alzheimer's disease research directed at increasing the understanding of the underlying disease process has led to the identification of several other potential targets for drug development strategies. Due to the complexity of the disease, it is possible that combination therapy -- concomitant use of agents with nonoverlapping or even synergistic mechanisms of action -- may represent the best means available to enhance treatment effectiveness. This review evaluates the available data on combination therapy in Alzheimer's disease and provides an expert opinion on the use and implementation of combination therapy in clinical practice.
Authors:
Martin R Farlow
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of neurotherapeutics     Volume:  4     ISSN:  1744-8360     ISO Abbreviation:  Expert Rev Neurother     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2005-04-27     Completed Date:  2006-04-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101129944     Medline TA:  Expert Rev Neurother     Country:  England    
Other Details:
Languages:  eng     Pagination:  799-808     Citation Subset:  IM    
Affiliation:
Department of Neurology, Indiana University School of Medicine, CL 299, 541 Clinical Drive, Indianapolis, IN 46202 5111, USA. mfarlow@iupui.edu
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / therapy*
Clinical Trials as Topic
Combined Modality Therapy / methods*
Drug Therapy, Combination
Expert Testimony
Humans
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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