| Utilizing Muscle-Derived Stem Cells to Enhance Long-Term Retention and Aesthetic Outcome of Autologous Fat Grafting: Pilot Study in Mice. | |
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MedLine Citation:
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PMID: 21607534 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Autologous fat grafting has been regarded as the ideal soft tissue filler for more than a century. Low long-term retention rate and unpredictability limit it from widespread clinical practice. Many theories for this have been proposed: lack of sufficient blood supply and subsequent necrosis is the most accepted. In this pilot study, we showed both macroscopically and microscopically the viability of muscle-derived stem cells (MDSCs) cotransplanted with fat placed intramuscularly for 3 months. MRI scanning showed a stronger fat signal in the MDSC-treated group than that of the control group. Moreover, histological evaluation exhibited well-preserved and intact fat cells in the MDSC-treated group. In contrast, the control group showed extensive fibrosis and fat graft loss. Furthermore, the MDSC-treated group possessed almost threefold greater capillary density than the control group. We conclude that cotransplantation of muscle-derived stem cells and autologous fat tissue improves the long-term survival of intramuscular fat transplants by promoting neovascularization. |
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Authors:
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Zhiqiang Ma; Duanyang Han; Peipei Zhang; Jenny F Yang; Yiqiang Wang; Yingbo Zhang; Daping Yang; Jianyu Liu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-24 |
Journal Detail:
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Title: Aesthetic plastic surgery Volume: - ISSN: 1432-5241 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7701756 Medline TA: Aesthetic Plast Surg Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Plastic Surgery, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Lu, Harbin, People's Republic of China, mazhiqiang79@hotmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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