Document Detail


Utilization of supplemental iron by premature infants fed fortified human milk.
MedLine Citation:
PMID:  10447137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We measured red blood cell iron incorporation (RBC-inc) in 13 human milk-fed premature infants (birthweight 1037 +/- 289 g, gestational age 27 +/- 2 wk, weight at start of study 1571 +/- 426 g) who were receiving full tube-feedings of human milk fortified with a commercial human milk fortifier (FortHM). The relative RBC-inc of supplemental iron (2 mg/kg/d of ferrous sulfate) was assessed using 57Fe sulfate mixed directly into a 24-h volume of FortHM, and 54Fe sulfate given as a bolus between two FortHM feedings the next day. RBC-inc was similar between the two methods of supplemental iron administration (4.7 +/- 2.5% vs 4.6 +/- 1.5%, respectively). Although these values are lower than RBC-inc expected from iron native to human milk, the relatively large amount of iron in the supplements contributed most of the iron incorporated into RBC by the infants. There was a significant positive correlation between the reticulocyte count and RBC-inc. As the high nutrient (especially calcium) content of the FortHM did not interfere with iron utilization, adding iron directly to FortHM, or incorporating it into commercial fortifiers, may be a practical method to provide iron to premature infants.
Authors:
G J Moody; R J Schanler; S A Abrams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  88     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-10-21     Completed Date:  1999-10-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  763-7     Citation Subset:  IM    
Affiliation:
USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Energy Intake
Erythrocyte Count
Food, Fortified*
Humans
Infant, Newborn
Infant, Premature
Iron, Dietary*
Milk, Human*
Grant Support
ID/Acronym/Agency:
M0-1-RR-00188/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Iron, Dietary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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