Document Detail


Utilization of skeletal muscle triacylglycerol during postexercise recovery in humans.
MedLine Citation:
PMID:  9688636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The utilization of muscle triacylglycerols was studied during and after prolonged bicycle ergometer exercise to exhaustion in eight healthy young men. Two days before exercise and in the postexercise recovery period, subjects were fed a carbohydrate-rich diet (65-70% of energy from carbohydrates). Exercise decreased muscle glycogen concentrations from 533 +/- 18 to 108 +/- 10 mmol/kg dry wt, whereas muscle triacylglycerol concentrations were unaffected (49 +/- 5 before vs. 49 +/- 8 mmol/kg dry wt after exercise). During the first 18 h after exercise, muscle glycogen concentrations were restored to 409 +/- 20 mmol/kg dry wt. In contrast, muscle triacylglycerol concentrations decreased (P < 0.05) to a nadir of 38 +/- 5 mmol/kg dry wt, and muscle lipoprotein lipase activity increased by 72% compared with values before exercise. Pulmonary respiratory exchange ratio values of 0.80-0.82 indicated a relatively high fractional lipid combustion despite the high carbohydrate intake. From 18 to 42 h of recovery, muscle glycogen synthesis was slow and muscle triacylglycerol concentrations and lipoprotein lipase activity were restored to the preexercise values. It is concluded that muscle triacylglycerol concentrations are not diminished during exhaustive glycogen-depleting exercise. However, in the postexercise recovery period, muscle glycogen resynthesis has high metabolic priority, resulting in postexercise lipid combustion despite a high carbohydrate intake. It is suggested that muscle triacylglycerols, and probably very low density lipoprotein triacylglycerols, are important in providing fuel for muscle metabolism in the postexercise recovery period.
Authors:
B Kiens; E A Richter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  275     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-09-16     Completed Date:  1998-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E332-7     Citation Subset:  IM; S    
Affiliation:
Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, DK-2100 Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / metabolism
Exercise / physiology*
Exercise Test
Fatty Acids, Nonesterified / blood
Glycogen / metabolism
Humans
Insulin / blood
Male
Muscle Fatigue / physiology*
Muscle, Skeletal / physiology*
Oxygen Consumption
Sports / physiology*
Time Factors
Triglycerides / metabolism*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Triglycerides; 11061-68-0/Insulin; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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