| Utilization of positron emission tomography in the management of patients with sarcoma. | |
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MedLine Citation:
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PMID: 19412096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) is being used with increased frequency in the care of patients with sarcoma. In this review, the recent literature covering all aspects of PET imaging in the management of patients with soft tissue and bone sarcomas will be discussed. RECENT FINDINGS: In a prospective multicenter study, PET imaging accurately detected primary tumors as well as lymph node and bone metastases in patients with sarcoma. Limitations in detecting lung metastasis can be overcome by using a hybrid PET/CT scanner. In patients with neurofibromatosis, 18F-FDG-PET demonstrated its application to detect and monitor for the malignant transformation of neurofibromas. Changes in tumor 18F-FDG uptake correlate significantly with histopathologic response and survival in patients with sarcoma. SUMMARY: PET imaging is emerging as an important imaging modality in the management of patients with sarcoma. Its applications include tumor grading, staging, therapeutic monitoring, and prognostication in adult and pediatric populations. |
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Authors:
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Matthias R Benz; Nishan Tchekmedyian; Fritz C Eilber; Noah Federman; Johannes Czernin; William D Tap |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in oncology Volume: 21 ISSN: 1531-703X ISO Abbreviation: Curr Opin Oncol Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-10 Completed Date: 2009-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007265 Medline TA: Curr Opin Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 345-51 Citation Subset: IM |
Affiliation:
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Departments of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California 90095, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bone Neoplasms
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pathology,
radionuclide imaging* Dideoxynucleosides / diagnostic use Fluorodeoxyglucose F18 / diagnostic use Humans Neoplasm Staging Osteosarcoma / pathology, radionuclide imaging* Positron-Emission Tomography / methods Radiopharmaceuticals / diagnostic use Sarcoma / pathology, radionuclide imaging* |
| Chemical | |
Reg. No./Substance:
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0/Dideoxynucleosides; 0/Radiopharmaceuticals; 25526-93-6/alovudine; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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