Document Detail


Utilization of narrow-band ultraviolet light B therapy and etanercept for the treatment of psoriasis (UNITE): efficacy, safety, and patient-reported outcomes.
MedLine Citation:
PMID:  18380206     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Moderate to severe psoriasis is a significant inflammatory disease that frequently requires systemic therapies to effectively treat the underlying disorder. Etanercept and narrow-band ultraviolet light B (NB-UVB) are widely used to treat this disease. OBJECTIVE: To evaluate the effectiveness, tolerability, and patient-reported outcomes of combination etanercept plus NB-UVB phototherapy in moderate to severe plaque psoriasis. METHODS: This 12-week, single-arm, open-label study evaluated the combination of etanercept 50 mg twice weekly and NB-UVB thrice weekly in 86 patients. The primary outcome measure was > or =75% improvement from baseline in the Psoriasis Area and Severity Index (PASI 75). Other measures included PASI 90, PASI 100, and the Dermatology Life Quality Index (DLQI). RESULTS: At week 12, 26.0% achieved PASI 100, 58.1% achieved PASI 90, and 84.9% of patients achieved PASI 75. Mean improvement from baseline in DLQI was 84.4%. No unexpected, untoward adverse events were noted. CONCLUSIONS: A 12-week course of etanercept plus NB-UVB phototherapy was well tolerated and produced clinically meaningful improvements in signs and symptoms of moderate to severe plaque psoriasis and in patient-reported outcomes. Further investigation of the safety and efficacy of the use of such combination for this indication in controlled clinical trials would be of interest.
Authors:
Leon Kircik; Jerry Bagel; Neil Korman; Alan Menter; Craig A Elmets; John Koo; Yu-Ching Yang; Chiun-Fang Chiou; Frank Dann; Seth R Stevens;
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of drugs in dermatology : JDD     Volume:  7     ISSN:  1545-9616     ISO Abbreviation:  J Drugs Dermatol     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-02     Completed Date:  2008-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160020     Medline TA:  J Drugs Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-53     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA. wedoderm@bellsouth.net
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MeSH Terms
Descriptor/Qualifier:
Adult
Combined Modality Therapy
Female
Humans
Immunoglobulin G / administration & dosage*,  adverse effects
Immunologic Factors / administration & dosage*,  adverse effects
Injections, Subcutaneous
Male
Middle Aged
Psoriasis / therapy*
Receptors, Tumor Necrosis Factor / administration & dosage*
Regression Analysis
Severity of Illness Index
Skin / pathology
Treatment Outcome
Ultraviolet Therapy*
Chemical
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunologic Factors; 0/Receptors, Tumor Necrosis Factor; 185243-69-0/TNFR-Fc fusion protein
Investigator
Investigator/Affiliation:
Bernard Goffe / ; Jerry Bagel / ; Jeffrey Crowley / ; David Fivenson / ; Mark Jackson / ; Leon Kircik / ; Neil Korman / ; Craig Elmets / ; Francisco Kerdel / ; Alexa Kimball / ; Julie Letsinger / ; Michael Zanoli / ; Joshua Zeichner / ; Alan Menter / ; Angela Moore / ; Henry Wong /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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