| Utilization of narrow-band ultraviolet light B therapy and etanercept for the treatment of psoriasis (UNITE): efficacy, safety, and patient-reported outcomes. | |
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MedLine Citation:
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PMID: 18380206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Moderate to severe psoriasis is a significant inflammatory disease that frequently requires systemic therapies to effectively treat the underlying disorder. Etanercept and narrow-band ultraviolet light B (NB-UVB) are widely used to treat this disease. OBJECTIVE: To evaluate the effectiveness, tolerability, and patient-reported outcomes of combination etanercept plus NB-UVB phototherapy in moderate to severe plaque psoriasis. METHODS: This 12-week, single-arm, open-label study evaluated the combination of etanercept 50 mg twice weekly and NB-UVB thrice weekly in 86 patients. The primary outcome measure was > or =75% improvement from baseline in the Psoriasis Area and Severity Index (PASI 75). Other measures included PASI 90, PASI 100, and the Dermatology Life Quality Index (DLQI). RESULTS: At week 12, 26.0% achieved PASI 100, 58.1% achieved PASI 90, and 84.9% of patients achieved PASI 75. Mean improvement from baseline in DLQI was 84.4%. No unexpected, untoward adverse events were noted. CONCLUSIONS: A 12-week course of etanercept plus NB-UVB phototherapy was well tolerated and produced clinically meaningful improvements in signs and symptoms of moderate to severe plaque psoriasis and in patient-reported outcomes. Further investigation of the safety and efficacy of the use of such combination for this indication in controlled clinical trials would be of interest. |
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Authors:
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Leon Kircik; Jerry Bagel; Neil Korman; Alan Menter; Craig A Elmets; John Koo; Yu-Ching Yang; Chiun-Fang Chiou; Frank Dann; Seth R Stevens; |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of drugs in dermatology : JDD Volume: 7 ISSN: 1545-9616 ISO Abbreviation: J Drugs Dermatol Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-04-02 Completed Date: 2008-07-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101160020 Medline TA: J Drugs Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 245-53 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA. wedoderm@bellsouth.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Combined Modality Therapy Female Humans Immunoglobulin G / administration & dosage*, adverse effects Immunologic Factors / administration & dosage*, adverse effects Injections, Subcutaneous Male Middle Aged Psoriasis / therapy* Receptors, Tumor Necrosis Factor / administration & dosage* Regression Analysis Severity of Illness Index Skin / pathology Treatment Outcome Ultraviolet Therapy* |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G; 0/Immunologic Factors; 0/Receptors, Tumor Necrosis Factor; 185243-69-0/TNFR-Fc fusion protein |
| Investigator | |
Investigator/Affiliation:
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Bernard Goffe / ; Jerry Bagel / ; Jeffrey Crowley / ; David Fivenson / ; Mark Jackson / ; Leon Kircik / ; Neil Korman / ; Craig Elmets / ; Francisco Kerdel / ; Alexa Kimball / ; Julie Letsinger / ; Michael Zanoli / ; Joshua Zeichner / ; Alan Menter / ; Angela Moore / ; Henry Wong / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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