| Utilization of fatty acids in perfused hypothermic dog kidney. | |
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MedLine Citation:
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PMID: 5098398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Utilization of oleic acid in whole dog kidneys perfused in vitro for 24 hr at 10 degrees C was studied, and the data were correlated with results on the utilization of oleic acid in kidney slices incubated in the same perfusate at 10 degrees C. Kidneys perfused without added oleate lost 35% of their total lipid content and 27% of their phospholipids. Addition of serum albumin-bound oleate to the perfusate prevented the loss of neutral lipid and reduced the loss of phospholipid to 8%. The kidney slices incorporated 29% of the added oleate into lipid and oxidized 3.2% to CO(2). Oleate apparently largely replaces endogenous fatty acids which are oxidized to meet the energy requirements of the kidney. The loss of phospholipid from the perfused organ is taken as an indication of cell damage, which may be reduced but is not prevented by the addition of oleate to the perfusate. |
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Authors:
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J S Huang; G L Downes; F O Belzer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of lipid research Volume: 12 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 1971 Sep |
Date Detail:
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Created Date: 1971-12-12 Completed Date: 1971-12-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 622-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Dioxide / metabolism Carbon Isotopes Cold Temperature Dogs Hydrogen-Ion Concentration Kidney / metabolism* Kidney Diseases / drug therapy Lipid Metabolism* Oleic Acids / metabolism*, therapeutic use Oxidation-Reduction Perfusion / instrumentation Phospholipids / metabolism* Pressure Protein Binding Serum Albumin Time Factors Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Carbon Isotopes; 0/Oleic Acids; 0/Phospholipids; 0/Serum Albumin; 0/Triglycerides; 124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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