| Utilization of endogenous lipid by the isolated perfused rat heart. | |
| | |
MedLine Citation:
|
PMID: 6049403 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. The lipids of the rat heart have been studied with regard to amount, classes present and fatty acid composition of free fatty acids, triglycerides and phospholipids. Myocardial lipid contained 300mumoles of total fatty acid/g. dry wt. of which only 2-4mumoles were free; the remainder was esterified, chiefly as phospholipid. Neutral esters, of which triglyceride was the principal form, made up 15% of the total fatty acids. 2. When normal hearts were perfused with a nutrient-free medium until exhaustion, the triglyceride concentration declined from 43 to 13mumoles/g. dry wt. The content of phospholipids, partial glycerides and cholesteryl esters did not change. When the lipids of the rat heart were labelled with [1-(14)C]palmitate before perfusion with non-nutrient medium, radioactivity disappeared from the triglyceride, diglyceride and free fatty acid fractions, but not from the phospholipid or other ester classes. 3. These experiments support the view that only a small fraction of the total cardiac lipid, principally triglycerides and to a smaller extent diglycerides, is available as a source of fuel in the absence of exogenous substrate. |
| | |
Authors:
|
R E Olson; R J Hoeschen |
Related Documents
:
|
16658353 - Changes in phospholipid composition of a winter wheat cultivar during germination at 2 ... 2280193 - An efficient synthesis of phosphatidylcholines. 10149953 - Development of novel dental cements. i. formulation of aluminoborate glasses. |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: The Biochemical journal Volume: 103 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1967 Jun |
Date Detail:
|
Created Date: 1967-12-14 Completed Date: 1967-12-14 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 796-801 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carbon Isotopes Cholesterol / analysis Chromatography, Gas Fatty Acids, Nonesterified / analysis Glycerides / analysis Lipid Metabolism* Lipids / analysis Male Myocardium / analysis, metabolism* Palmitic Acids / metabolism Perfusion Phospholipids / analysis Rats Triglycerides / analysis |
| Chemical | |
Reg. No./Substance:
|
0/Carbon Isotopes; 0/Fatty Acids, Nonesterified; 0/Glycerides; 0/Lipids; 0/Palmitic Acids; 0/Phospholipids; 0/Triglycerides; 57-88-5/Cholesterol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: [35S]thiosulphate oxidation by rat liver mitochondria in the presence of glutathione.
Next Document: Hyaluronidase activity in lysosomes of bone tissue.