Document Detail

Utilization of dietary nucleic acid purines for nucleotide and nucleic acid synthesis in the mouse.
MedLine Citation:
PMID:  776369     Owner:  NLM     Status:  MEDLINE    
Three preparations of radioactive yeast nucleic acids were fed to mice. One was labeled predominantly in the guanine moiety, one was labeled predominantly in the adenine moiety, and in one adenine and guanine were labeled equally. Most of the nucleic acid purines produced by digestion were excreted in the urine. However, a small amount was utilized for nucleotide and nucleic acid synthesis in the mouse tissues. Small intestine, liver and skeletal muscle contained most of the purines that were retained in the tissues. Dietary nucleic acid adenine appeared to be utilized somewhat more efficiently than was dietary nucleic acid guanine.
P W Burridge; R A Woods; J F Henderson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of biochemistry     Volume:  54     ISSN:  0008-4018     ISO Abbreviation:  Can. J. Biochem.     Publication Date:  1976 May 
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0421034     Medline TA:  Can J Biochem     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  500-6     Citation Subset:  IM    
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MeSH Terms
Adenine / metabolism
Administration, Oral
DNA / administration & dosage,  biosynthesis,  metabolism*
Guanine / metabolism
Intestine, Small / metabolism
Liver / metabolism
Mice, Inbred ICR
Muscles / metabolism
Organ Specificity
Purines / biosynthesis*
RNA / administration & dosage,  biosynthesis,  metabolism*
Saccharomyces cerevisiae
Reg. No./Substance:
0/Purines; 63231-63-0/RNA; 73-24-5/Adenine; 73-40-5/Guanine; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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