Document Detail


Utilization of antihypertensives, antidepressants, antipsychotics, and hormones in Alzheimer disease.
MedLine Citation:
PMID:  20975515     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study explores the longitudinal relationship between patient characteristics and use of 4 drug classes (antihypertensives, antidepressants, antipsychotics, and hormones) that showed significant changes in use rates over time in patients with Alzheimer disease. Patient/caregiver-reported prescription medication usage was categorized by drug class for 201 patients from the Predictors Study. Patient characteristics included use of cholinesterase inhibitors and/or memantine, function, cognition, living situation, baseline age, and sex. Assessment interval, year of study entry, and site were controlled for. Before adjusting for covariates, useage increased for antihypertensives (47.8% to 62.2%), antipsychotics (3.5% to 27.0%), and antidepressants (32.3% to 40.5%); use of hormones decreased (19.4% to 5.4%). After controlling for patient characteristics, effects of time on the use of antidepressants were no longer significant. Antihypertensive use was associated with poorer functioning, concurrent use of memantine, and older age. Antipsychotic use was associated with poorer functioning and poorer cognition. Antidepressant use was associated with younger age, poorer functioning, and concurrent use of cholinesterase inhibitors and memantine. Hormone use was associated with being female and younger age. Findings suggest accurate modeling of the Alzheimer disease treatment paradigm for certain subgroups of patients should include antihypertensives and antipsychotics in addition to cholinesterase inhibitors and memantine.
Authors:
Carolyn W Zhu; Elayne E Livote; Kristin Kahle-Wrobleski; Nikolaos Scarmeas; Marilyn Albert; Jason Brandt; Deborah Blacker; Mary Sano; Yaakov Stern
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Alzheimer disease and associated disorders     Volume:  25     ISSN:  1546-4156     ISO Abbreviation:  Alzheimer Dis Assoc Disord     Publication Date:    2011 Apr-Jun
Date Detail:
Created Date:  2011-05-23     Completed Date:  2011-10-19     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  8704771     Medline TA:  Alzheimer Dis Assoc Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  144-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / drug therapy*
Antidepressive Agents / therapeutic use*
Antihypertensive Agents / therapeutic use*
Antipsychotic Agents / therapeutic use*
Female
Hormones / therapeutic use*
Humans
Longitudinal Studies
Male
Physician's Practice Patterns
Grant Support
ID/Acronym/Agency:
AG07370/AG/NIA NIH HHS; R01 AG007370/AG/NIA NIH HHS; R01 AG007370-07/AG/NIA NIH HHS; RR00645/RR/NCRR NIH HHS; U01AG010483/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Antidepressive Agents; 0/Antihypertensive Agents; 0/Antipsychotic Agents; 0/Hormones
Comments/Corrections

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