| Utility of urinary pyridinoline and deoxypyridinoline ratio for diagnosis of osteoarthritis at temporomandibular joint. | |
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MedLine Citation:
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PMID: 15061709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Pyridinoline (Pyr) and deoxypyridinoline (Dpyr) collagen cross-links are known markers of bone and cartilage turnover that are found in urine in various diseases. The present study was designed to quantify Pyr and Dpyr levels in urine of patients with osteoarthritis (OA) of the temporomandibular joint (TMJ), and to evaluate whether their concentrations are related to specific pathologic findings in the TMJ. METHODS: Urine samples were obtained from 12 patients with OA of the TMJ and 16 asymptomatic controls, and following appropriate preparation, analyzed by high-performance liquid chromatography (HPLC) and fluorescence spectroscopy for Pyr and Dpyr. RESULTS: The urinary concentration of Pyr and the Pyr to Dpyr (Pyr/Dpyr) ratio were significantly higher (P < 0.05) in OA patients than in the controls (182.2 +/- 86.5 pmol/ml vs. 115.6 +/- 27.9 pmol/ml and 4.00 +/- 1.53 pmol/ml vs. 2.86 +/- 0.97 pmol/ml, respectively). However, the Pyr/Dpyr ratio was not associated with any specific clinical or radiographic findings. CONCLUSION: These findings suggest that the level of Pyr and the Pyr/Dpyr ratio in urine may be a useful diagnostic indicator for intra-articular pathologic changes during TMJ OA. |
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Authors:
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K Tanimoto; S Ohno; M Imada; K Honda; M Ohno-Nakahara; S Kapila; K Tanne |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology Volume: 33 ISSN: 0904-2512 ISO Abbreviation: J. Oral Pathol. Med. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-05 Completed Date: 2004-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8911934 Medline TA: J Oral Pathol Med Country: Denmark |
Other Details:
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Languages: eng Pagination: 218-23 Citation Subset: D; IM |
Affiliation:
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Department of Orthodontics & Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, 734-8553 Hiroshima, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acids / urine* Biological Markers / urine Chromatography, High Pressure Liquid Female Humans Male Middle Aged Osteoarthritis / diagnosis*, radiography, urine Pain Measurement Spectrometry, Fluorescence Statistics, Nonparametric Temporomandibular Joint Disorders / diagnosis*, radiography, urine |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Biological Markers; 63800-01-1/pyridinoline; 90032-33-0/deoxypyridinoline |
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