Document Detail

Utility of tissue Doppler imaging to predict exercise capacity in hypertrophic cardiomyopathy: comparison with B-type natriuretic peptide.
MedLine Citation:
PMID:  19477377     Owner:  NLM     Status:  In-Process    
BACKGROUND: Recent reports suggest that left ventricular diastolic function assessed by tissue Doppler imaging (TDI) and plasma B-type natriuretic peptide (BNP) levels can relate to functional status in patients with hypertrophic cardiomyopathy (HCM). However, it is unclear which is more useful to predict the exercise capacity in HCM patients without systolic impairment and/or atrial fibrillation, TDI or BNP levels.
PURPOSE: The present study directly compared the clinical relevance of assessing diastolic function using TDI and measuring the plasma BNP level in patients with HCM.
METHODS AND SUBJECTS: We evaluated diastolic function using TDI as well as plasma BNP levels in 31 patients (52.2+/-16.9 years of age; 20 males) with HCM and examined the relationship of these values to exercise capacity (peak O(2) consumption (VO(2))) measured by cardiopulmonary exercise tests.
RESULTS: Average peak VO(2) was 18.5+/-4.7 ml/(kg min). Although the E/A ratio by transmitral flow was not correlated with peak VO(2), the lateral E/E(a) ratio assessed by TDI was significantly correlated with peak VO(2) (r=-0.52, p=0.003). On the other hand, plasma BNP level was not significantly related to peak VO(2) but NYHA class.
CONCLUSIONS: Assessment of diastolic function using TDI, not plasma BNP levels, is more useful for predicting objective exercise capacity in HCM patients without systolic impairment and/or atrial fibrillation.
Hiroaki Kitaoka; Toru Kubo; Makoto Okawa; Takayoshi Hirota; Kayo Hayato; Naohito Yamasaki; Yoshihisa Matsumura; Yoshinori L Doi
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Publication Detail:
Type:  Journal Article     Date:  2009-02-20
Journal Detail:
Title:  Journal of cardiology     Volume:  53     ISSN:  1876-4738     ISO Abbreviation:  J Cardiol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  361-7     Citation Subset:  IM    
Division of Cardiology, Department of Medicine and Geriatrics, Kochi Medical School, Kochi, Japan.
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