Document Detail

Utility of serology in determining Helicobacter pylori eradication after therapy.
MedLine Citation:
PMID:  9559206     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the usefulness of four serological tests in confirming cure of H pylori infection before the previously reported six-month post-treatment delay.
PATIENTS AND METHODS: As part of a prospective, blinded, controlled trial, in which patients with duodenal ulcers were randomized to receive different combinations of antibiotics, serum samples were obtained in 89 patients before treatment, as well as on several occasions after treatment. Antibody titres were determined by ELISA with Bio-Rad immunoglobulin (Ig) A, Bio-Rad IgG, Pyloriset EIA-A for IgA and Pyloriset EIA-G for IgG. Eradication was confirmed with antral biopsy three months after therapy.
RESULTS: The percentage drop in titre following treatment was significantly larger for the group of patients who were treated successfully with all four kits. Optimal cut-offs for identifying successful therapy were determined, and accuracy improved as the interval between testing and therapy was prolonged. Six months after therapy, the IgG test from Bio-Rad achieved 100% sensitivity and 80% specificity, and that from Pyloriset achieved 88% sensitivity and 100% specificity. At three months, however, test performance was quite good, with 90% sensitivity and 80% specificity when using a Pyloriset IgA titre drop of 20% or greater to predict successful eradication.
CONCLUSION: Serology is a simple, easily available, noninvasive method that exhibits good positive predictive value in the confirmation of successful cure of H pylori infection three or six months after treatment.
C A Fallone; V G Loo; A N Barkun
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of gastroenterology = Journal canadien de gastroenterologie     Volume:  12     ISSN:  0835-7900     ISO Abbreviation:  Can. J. Gastroenterol.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-06-11     Completed Date:  1998-06-11     Revised Date:  2014-01-17    
Medline Journal Info:
Nlm Unique ID:  8807867     Medline TA:  Can J Gastroenterol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  117-24     Citation Subset:  IM    
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MeSH Terms
Amoxicillin / administration & dosage
Anti-Bacterial Agents / administration & dosage
Anti-Ulcer Agents / administration & dosage
Antibodies, Bacterial / blood*
Double-Blind Method
Drug Therapy, Combination
Duodenal Ulcer / drug therapy,  microbiology
Enzyme-Linked Immunosorbent Assay
Helicobacter Infections / blood,  diagnosis*,  drug therapy
Helicobacter pylori / immunology*
Immunoenzyme Techniques
Immunoglobulin A / blood
Immunoglobulin G / blood
Metronidazole / administration & dosage
Organometallic Compounds / administration & dosage
Predictive Value of Tests
Sensitivity and Specificity
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Ulcer Agents; 0/Antibodies, Bacterial; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Organometallic Compounds; 140QMO216E/Metronidazole; 804826J2HU/Amoxicillin; HS813P8QPX/bismuth tripotassium dicitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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