Document Detail

Utility of sepsis evaluation in infants 90 days of age or younger with fever and clinical bronchiolitis.
MedLine Citation:
PMID:  14688564     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify the clinical utility of obtaining blood, urine and cerebrospinal fluid for bacterial culture among febrile infants <90 days of age with clinical bronchiolitis. DESIGN: Retrospective chart review from 1995 to 2000. SETTING: Urban emergency department of a tertiary children's hospital. PARTICIPANTS: All infants <90 days of age presenting with fever and clinical bronchiolitis. MAIN OUTCOME MEASURES: Result of the cultures of blood, urine and cerebrospinal fluid. RESULTS: Of 3051 (11%) febrile infants, 329 met criteria for clinical bronchiolitis. Blood for culture was obtained from 309 (94%), urine for culture was obtained from 273 (83%) and cerebrospinal fluid for culture was obtained from 200 (61%). One hundred eighty-seven (57%) infants had all 3 specimens sent for culture. No cases of bacteremia [0%; 95% confidence interval (CI), 0, 1.1%] or meningitis (0%; 95% CI 0, 1.8%) occurred among these infants. However, 6 infants (2%; 95% CI 0.8, 5.7%), all male, had a culture of urine consistent with infection (4 Escherichia coli, 1 Staphylococcus aureus, 1 viridans streptococci). CONCLUSION: The risk of bacteremia or meningitis among infants <90 days with fever and bronchiolitis is low in this age group. The risk of urinary tract infection in this age group is also low, but not negligible, at 2%.
Elliot Melendez; Marvin B Harper
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  22     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-22     Completed Date:  2004-02-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1053-6     Citation Subset:  IM    
Department of Medicine, Children's Hospital Boston, MA 02115, USA.
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MeSH Terms
Anti-Bacterial Agents / administration & dosage
Bacteremia / drug therapy,  epidemiology*,  microbiology*
Blood / microbiology
Bronchiolitis / drug therapy,  epidemiology*,  microbiology*
Cross-Sectional Studies
Emergency Service, Hospital
Fever / diagnosis,  drug therapy,  epidemiology*
Follow-Up Studies
Infant, Newborn
Microbial Sensitivity Tests
Retrospective Studies
Risk Assessment
Severity of Illness Index
Treatment Outcome
Urban Population
Urine / microbiology
Reg. No./Substance:
0/Anti-Bacterial Agents
Comment In:
Pediatr Infect Dis J. 2004 Apr;23(4):376-7; author reply 377   [PMID:  15071307 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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