| Utility of recovery cycle with two conditioning pulses for detection of impaired axonal slow potassium current in ALS. | |
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MedLine Citation:
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PMID: 20538517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Slow potassium current (I(Ks)) is important in controlling nerve excitability and its impairment is known in various neurological diseases, including amyotrophic lateral sclerosis (ALS). I(Ks) gives rise to the late subexcitability phase of the recovery cycle, which can be amplified by the use of multiple conditioning pulses. The clinical utility of this technique has not previously been explored. METHODS: Nerve excitability tests, including recovery cycles with single and double conditioning pulses 4ms apart (RC and RC2, respectively) were performed in patients with ALS and control subjects. Late subexcitability values obtained by RC and RC2 were compared in both groups. RESULTS: RC2 was well tolerated in all the subjects. The threshold changes in late subexcitability by RC2 were greater than those by RC in both groups (mean (%): RC, 16.0/13.3; RC2, 34.9/29.4 (Control/ALS)). The ALS group showed lower threshold changes than controls by both methods. Statistical analysis between the ALS and control groups provided smaller P value by RC2 (P=0.018) than by RC (P=0.046). Also, RC2 provided non-significant, but slightly more distinguishing non-parametric rank analysis and greater Area Under the Curve (AUC) by Receiver Operating Characteristic (ROC). RC2 produced more identifiable single peak for late subexcitability than RC in an ALS patient whose late subexcitability was decreased. CONCLUSIONS: Two conditioning stimuli provide greater threshold change for late subexcitability and possibly clearer identification of a peak threshold change than conventional recovery cycle. The findings obtained by this new protocol reinforce the previously reported impairment of I(Ks) in ALS. SIGNIFICANCE: Amplification of I(Ks) by double conditioning pulses is applicable in humans and may help elucidating its clinical significance in pathophysiology in neurological diseases. |
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Authors:
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Yoshiko Shibuta; Hiroyuki Nodera; Atsuko Nodera; Takahiro Okita; Kotaro Asanuma; Yuishin Izumi; Ryuji Kaji |
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Publication Detail:
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Type: Journal Article Date: 2010-06-09 |
Journal Detail:
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Title: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Volume: 121 ISSN: 1872-8952 ISO Abbreviation: Clin Neurophysiol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883319 Medline TA: Clin Neurophysiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 2117-20 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Neurology, Tokushima University, Tokushima, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology* Adult Aged Aged, 80 and over Amyotrophic Lateral Sclerosis / pathology, physiopathology* Axons / physiology* Case-Control Studies Electric Stimulation / methods Electromyography / methods Female Humans Male Middle Aged Potassium Channels / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Potassium Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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