Document Detail


Utility of phenotypic dermal indices in the detection of Down syndrome patients.
MedLine Citation:
PMID:  18298007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Down syndrome (DS) is the most common cause of mental retardation. The frequency of DS patients is about 1:800 and is mainly because of the presence of extra copy of chromosome number 21. Dermatoglyphic has been well established as a diagnostic aid in number of diseases having hereditary basis. Dermatoglyphic data was obtained by the use of ink and prints on a paper, from 15 cytogenetically confirmed patients of Down syndrome attending to the genetic clinic at BPKIHS. The data were correlated and compared with equal number of controls. Dermatoglyphic prints were used to evaluate the variation in the fingerprint patterns, the presence of simian crease and the difference in 'atd' 'dat' and 'adt' angles between the control and the DS patients. The results showed that both the 'atd' and 'adt' angles differed significantly from the control group. The dactylography study revealed higher incidence of loops and lower incidence of whorls in the DS patients as compared with the controls. This method is non-invasive and cost effective. The observed changes in the 'atd' and 'adt' angles plus the fingerprint patterns in the dermatoglyphic study proved that this simple technique could be a valuable tool for selecting patients of DS for cytogenetics analysis.
Authors:
D Masjkey; S Bhattacharya; S Dhungel; C B Jha; S Shrestha; S R Ghimire; D Rai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nepal Medical College journal : NMCJ     Volume:  9     ISSN:  -     ISO Abbreviation:  Nepal Med Coll J     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-02-26     Completed Date:  2008-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101129937     Medline TA:  Nepal Med Coll J     Country:  Nepal    
Other Details:
Languages:  eng     Pagination:  217-21     Citation Subset:  IM    
Affiliation:
Department of Anatomy, B. P. Koirala Institute of Health Sciences, Dharan, Nepal. dhiraj_mask@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Dermatoglyphics*
Down Syndrome / diagnosis*,  genetics,  physiopathology
Health Status Indicators
Humans
Phenotype*
Pilot Projects
Skin / anatomy & histology,  physiopathology
Skin Diseases / diagnosis*,  etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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