| Utility of napsin a and thyroid transcription factor 1 in differentiating metastatic pulmonary from non-pulmonary adenocarcinoma in pleural effusion. | |
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MedLine Citation:
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PMID: 21525739 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: It was our aim to evaluate the usefulness of napsin A and thyroid transcription factor 1 (TTF-1) in the differential diagnosis of metastatic pulmonary and non-pulmonary adenocarcinomas (ACs) in pleural effusion. Study Design: A total of 84 pleural effusion fluid cell blocks were collected from metastatic ACs. There were 53 pulmonary ACs and 31 non-pulmonary ACs. Immunohistochemical staining was performed with antibodies against napsin A and TTF-1. Results: Napsin A was positive in 44/53 (83%) cases of pulmonary ACs, and TTF-1 was positive in 30/53 (57%) cases of pulmonary ACs. All non-pulmonary ACs were negative for napsin A and TTF-1. Napsin A showed a reactivity in >75% of the tumor cells in 36 of the 44 positive cases (82%), whereas TTF-1 showed a reactivity in >75% of the tumor cells only in 6 of the 30 positive cases (20%; p < 0.01). Poorly differentiated pulmonary ACs expressed napsin A (73%) more frequently than TTF-1 (53%), but this was not statistically significant (p = 0.45). Conclusion: We conclude that napsin A is superior to TTF-1 with regard to distinguishing between metastatic pulmonary and non-pulmonary ACs in cell blocks prepared from malignant pleural effusions. |
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Authors:
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Jo-Heon Kim; Young-Sill Kim; Yoo-Duk Choi; Ji-Shin Lee; Chang-Soo Park |
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Publication Detail:
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Type: Journal Article Date: 2011-04-27 |
Journal Detail:
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Title: Acta cytologica Volume: 55 ISSN: 0001-5547 ISO Abbreviation: Acta Cytol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-04-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370307 Medline TA: Acta Cytol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 266-70 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Department of Pathology, Jeju National University Medical School, Jeju, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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