| Utility of multivariate analysis in modeling the effects of raw material properties and operating parameters on granule and ribbon properties prepared in roller compaction. | |
| | |
MedLine Citation:
|
PMID: 18777445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This article aimed to model the effects of raw material properties and roller compactor operating parameters (OPs) on the properties of roller compacted ribbons and granules with the aid of principal component analysis (PCA) and partial least squares (PLS) projection. A database of raw material properties was established through extensive physical and mechanical characterization of several microcrystalline cellulose (MCC) and lactose grades and their blends. A design of experiment (DoE) was used for ribbon production. PLS models constructed with only OP-modeled roller compaction (RC) responded poorly. Inclusion of raw material properties markedly improved the goodness of fit (R(2) = .897) and model predictability (Q(2) = 0.72). |
| | |
Authors:
|
Josephine L P Soh; Feng Wang; Nathan Boersen; Rodolfo Pinal; Garnet E Peck; M Teresa Carvajal; James Cheney; Hedinn Valthorsson; Jim Pazdan |
Related Documents
:
|
22767445 - Lactate detection in inducible and orthotopic her2/neu mammary gland tumours in mouse m... 6203715 - Principal component analysis of event-related potentials: simulation studies demonstrat... 15627605 - Complex fmri analysis with unrestricted phase is equivalent to a magnitude-only model. 9252835 - Multipoint dissolution specification and acceptance sampling rule based on profile mode... 22068575 - Applying the performance partnership model to smoking cessation: lessons learned by the... 20661995 - Improved model for myocardial diffuse reflectance spectra by including mitochondrial cy... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Drug development and industrial pharmacy Volume: 34 ISSN: 1520-5762 ISO Abbreviation: Drug Dev Ind Pharm Publication Date: 2008 Oct |
Date Detail:
|
Created Date: 2008-09-29 Completed Date: 2008-11-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7802620 Medline TA: Drug Dev Ind Pharm Country: United States |
Other Details:
|
Languages: eng Pagination: 1022-35 Citation Subset: IM |
Affiliation:
|
Department of Industrial and Physical Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, IN 47907, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cellulose Excipients Lactose Least-Squares Analysis Multivariate Analysis Principal Component Analysis Tablets* Technology, Pharmaceutical* |
| Chemical | |
Reg. No./Substance:
|
0/Excipients; 0/Tablets; 0/microcrystalline cellulose; 63-42-3/Lactose; 9004-34-6/Cellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of stimulus features and instruction on response coding, selection, and inhibition: evidence...
Next Document: Proteomic profiling of beta-cells using a classical approach - two-dimensional gel electrophoresis.