Document Detail


Utility of multivariate analysis in modeling the effects of raw material properties and operating parameters on granule and ribbon properties prepared in roller compaction.
MedLine Citation:
PMID:  18777445     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This article aimed to model the effects of raw material properties and roller compactor operating parameters (OPs) on the properties of roller compacted ribbons and granules with the aid of principal component analysis (PCA) and partial least squares (PLS) projection. A database of raw material properties was established through extensive physical and mechanical characterization of several microcrystalline cellulose (MCC) and lactose grades and their blends. A design of experiment (DoE) was used for ribbon production. PLS models constructed with only OP-modeled roller compaction (RC) responded poorly. Inclusion of raw material properties markedly improved the goodness of fit (R(2) = .897) and model predictability (Q(2) = 0.72).
Authors:
Josephine L P Soh; Feng Wang; Nathan Boersen; Rodolfo Pinal; Garnet E Peck; M Teresa Carvajal; James Cheney; Hedinn Valthorsson; Jim Pazdan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  34     ISSN:  1520-5762     ISO Abbreviation:  Drug Dev Ind Pharm     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-29     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1022-35     Citation Subset:  IM    
Affiliation:
Department of Industrial and Physical Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, IN 47907, USA.
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MeSH Terms
Descriptor/Qualifier:
Cellulose
Excipients
Lactose
Least-Squares Analysis
Multivariate Analysis
Principal Component Analysis
Tablets*
Technology, Pharmaceutical*
Chemical
Reg. No./Substance:
0/Excipients; 0/Tablets; 0/microcrystalline cellulose; 63-42-3/Lactose; 9004-34-6/Cellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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