Document Detail

Utility of immunohistochemical analysis for cyclo-oxygenase 2 in the differential diagnosis of osteoblastoma and osteosarcoma.
MedLine Citation:
PMID:  16822878     Owner:  NLM     Status:  MEDLINE    
AIMS: To study the immunoexpression of cyclo-oxygenase (COX) 2 in osteoblastomas (OBs) and osteosarcomas (OSs), and to assess the utility of immunohistochemical analysis for COX 2 in the differential diagnosis of the two tumour forms.
METHODS: The immunohistochemical features of COX 2 were studied in 11 OBs and 30 OSs, including 26 high-grade OSs (16 osteoblastic, 7 chondroblastic, and 3 fibroblastic) and 4 low-grade OSs.
RESULTS: Tumour cells from all 11 OBs unequivocally showed diffuse, intense and cytoplasmic immunoreactivity for COX 2. Strong cytoplasmic expression of COX 2 was observed in 5 of 26 (19%) high-grade OSs, all chondroblastic. In one osteoblastic-type OS, COX 2 was expressed in the chondroblastic component, but this tumour was considered to be COX 2 negative. No COX 2 expression was noted in atypical osteoblastic cells. Staining in the four low-grade OSs was negative.
CONCLUSION: The results of immunohistochemical analysis of COX 2 suggest that in addition to the routine histopathological evaluation, COX 2 is a valuable diagnostic marker in the distinction between OB and OS.
Ako Hosono; Umio Yamaguchi; Atsushi Makimoto; Makoto Endo; Atsuko Watanabe; Tadakazu Shimoda; Mitsunori Kaya; Tadaki Matsumura; Hiroshi Sonobe; Tomomi Kusumi; Takehiko Yamaguchi; Tadashi Hasegawa
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Multicenter Study     Date:  2006-07-05
Journal Detail:
Title:  Journal of clinical pathology     Volume:  60     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-04     Completed Date:  2007-05-08     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  410-4     Citation Subset:  AIM; IM    
Division of Paediatric Oncology, National Cancer Center Hospital, Tokyo, Japan.
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MeSH Terms
Bone Neoplasms / diagnosis*,  pathology
Clinical Enzyme Tests / methods*
Cyclooxygenase 2 / metabolism*
Diagnosis, Differential
Immunoenzyme Techniques
Middle Aged
Osteoblastoma / diagnosis*,  pathology
Osteosarcoma / diagnosis*,  pathology
Tumor Markers, Biological / metabolism*
Reg. No./Substance:
0/Tumor Markers, Biological; EC 2

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