| Utility of immunohistochemical analysis for cyclo-oxygenase 2 in the differential diagnosis of osteoblastoma and osteosarcoma. | |
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MedLine Citation:
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PMID: 16822878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To study the immunoexpression of cyclo-oxygenase (COX) 2 in osteoblastomas (OBs) and osteosarcomas (OSs), and to assess the utility of immunohistochemical analysis for COX 2 in the differential diagnosis of the two tumour forms. METHODS: The immunohistochemical features of COX 2 were studied in 11 OBs and 30 OSs, including 26 high-grade OSs (16 osteoblastic, 7 chondroblastic, and 3 fibroblastic) and 4 low-grade OSs. RESULTS: Tumour cells from all 11 OBs unequivocally showed diffuse, intense and cytoplasmic immunoreactivity for COX 2. Strong cytoplasmic expression of COX 2 was observed in 5 of 26 (19%) high-grade OSs, all chondroblastic. In one osteoblastic-type OS, COX 2 was expressed in the chondroblastic component, but this tumour was considered to be COX 2 negative. No COX 2 expression was noted in atypical osteoblastic cells. Staining in the four low-grade OSs was negative. CONCLUSION: The results of immunohistochemical analysis of COX 2 suggest that in addition to the routine histopathological evaluation, COX 2 is a valuable diagnostic marker in the distinction between OB and OS. |
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Authors:
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Ako Hosono; Umio Yamaguchi; Atsushi Makimoto; Makoto Endo; Atsuko Watanabe; Tadakazu Shimoda; Mitsunori Kaya; Tadaki Matsumura; Hiroshi Sonobe; Tomomi Kusumi; Takehiko Yamaguchi; Tadashi Hasegawa |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Multicenter Study Date: 2006-07-05 |
Journal Detail:
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Title: Journal of clinical pathology Volume: 60 ISSN: 0021-9746 ISO Abbreviation: J. Clin. Pathol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-04 Completed Date: 2007-05-08 Revised Date: 2013-06-07 |
Medline Journal Info:
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Nlm Unique ID: 0376601 Medline TA: J Clin Pathol Country: England |
Other Details:
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Languages: eng Pagination: 410-4 Citation Subset: AIM; IM |
Affiliation:
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Division of Paediatric Oncology, National Cancer Center Hospital, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Bone Neoplasms / diagnosis*, pathology Child Clinical Enzyme Tests / methods* Cyclooxygenase 2 / metabolism* Diagnosis, Differential Female Humans Immunoenzyme Techniques Male Middle Aged Osteoblastoma / diagnosis*, pathology Osteosarcoma / diagnosis*, pathology Tumor Markers, Biological / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological; EC 1.14.99.1/Cyclooxygenase 2 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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