Document Detail


Utility and health-related quality of life in prostate cancer patients 12 months after radical prostatectomy or radiation therapy.
MedLine Citation:
PMID:  19901935     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study aims to examine and compare changes in quality of life after two common treatments for prostate cancer (PC), radical prostatectomy (RP) and radiation therapy (RT). Patients newly diagnosed with localized PC, scheduled to receive RP (n=68) or RT (n=66), completed three cancer/PC-specific psychometric instruments and three PC-specific utility instruments before treatment, and 2 and 12 months after treatment. We assessed the magnitude and time course of changes in psychometric and utility measures, and differences between treatments. The results showed that RP was associated with significant urinary and sexual dysfunction; RT caused bowel problems. Fatigue and pain were common to both. RP patients reported more problems with physical, role and social function. Utilities decreased significantly after both treatments. Effects were most severe 2 months post treatment, and then showed some recovery, but many endured for 1 year. After 1 year, 30-60% of patients had utility scores that were clinically significantly worse than at baseline. Secondary androgen deprivation therapy also significantly decreased psychometric and utility measures of quality of life. Many adverse symptoms reported 2 months after RP and RT endure for 1 year. Despite different symptom profiles, RP and RT result in similar utility decrements.
Authors:
M D Krahn; K E Bremner; G Tomlinson; G Naglie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-01
Journal Detail:
Title:  Prostate cancer and prostatic diseases     Volume:  12     ISSN:  1476-5608     ISO Abbreviation:  Prostate Cancer Prostatic Dis.     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-10     Completed Date:  2010-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815755     Medline TA:  Prostate Cancer Prostatic Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  361-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, and Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Aged
Androgen Antagonists / adverse effects
Health Status*
Humans
Male
Middle Aged
Prostatectomy / adverse effects*
Prostatic Neoplasms / radiotherapy*,  surgery*
Psychometrics
Quality of Life*
Grant Support
ID/Acronym/Agency:
006169//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Androgen Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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