Document Detail


Utility of foramen ovale electrodes in mesial temporal lobe epilepsy.
MedLine Citation:
PMID:  24605889     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: To determine the ability of foramen ovale electrodes (FOEs) to localize epileptogenic foci after inconclusive noninvasive investigations in patients with suspected mesial temporal lobe epilepsy (MTLE).
METHODS: We identified patients with medically intractable epilepsy who had undergone FOE investigation for initial invasive monitoring at our institution between 2005 and 2012. Indications for initiating FOE investigation were grouped into four categories: (1) bilateral anterior temporal ictal activity on scalp electroencephalography (EEG), (2) unclear laterality of scalp EEG onset due to muscle artifact or significant delay following clinical manifestation, (3) discordance between ictal and interictal discharges, and (4) investigation of a specific anatomic abnormality or competing putative focus. The FOE investigation was classified as informative if it provided sufficient evidence to make a treatment decision.
RESULTS: Forty-two consecutive patients underwent FOE investigation, which was informative in 38 patients (90.5%). Of these 38 patients, 24 were determined to be appropriate candidates for resective surgery. Five were localized sufficiently for surgery, but were considered high risk for verbal memory deficit, and nine were deemed poor surgical candidates because of bilateral ictal origins. The remaining 4 of 42 patients had inconclusive FOE studies and were referred for further invasive investigation. Of the 18 patients who underwent resective surgery, 13 (72%) were seizure-free (Engel class I) at last follow-up (mean 22.5 months).
SIGNIFICANCE: More than 90% of our 42 FOE studies provided sufficient evidence to render treatment decisions. When undertaken with an appropriate hypothesis, FOE investigations are a minimally invasive and efficacious means for evaluating patients with suspected MTLE after an inconclusive noninvasive investigation. A PowerPoint slide summarizing this article is available for download in the Supporting Information section here.
Authors:
Sameer A Sheth; Joshua P Aronson; Mouhsin M Shafi; H Wesley Phillips; Naymee Velez-Ruiz; Brian P Walcott; Churl-Su Kwon; Matthew K Mian; Andrew R Dykstra; Andrew Cole; Emad N Eskandar
Related Documents :
23690099 - The evaluation of coagulation parameters and vessel involvement in behcet' s disease. a...
24235269 - Fragmented qrs complex in adult patients with ebstein's anomaly and its association wit...
24084059 - Serum immunoglobulins in the infected and convalescent phases in community-acquired pne...
24612379 - Complement activation and its prognostic role in post-cardiac arrest patients.
512689 - Abnormal leukocyte electrophoretic mobility in myotonic dystrophy.
24165009 - Electrophysiological study for nerve root entrapment in patients with isthmic spondylol...
11007379 - Left ventricular hypertrophy and clinical outcome in capd patients.
17723939 - Patients who have dilated cardiomyopathy must have a trial of bridge to recovery: the c...
6707669 - Central nervous system involvement in optic neuritis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-7
Journal Detail:
Title:  Epilepsia     Volume:  -     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Wiley Periodicals, Inc. © 2014 International League Against Epilepsy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Air-Stable (Phenylbuta-1,3-diynyl)palladium(II) Complexes: Highly Active Initiators for Living Polym...
Next Document:  Orientational Order of Two Fluoro- and Isothiocyanate-Substituted Nematogens by Combination of 13C N...