Document Detail

Utility of cardiac biomarkers for the diagnosis of type V myocardial infarction after coronary artery bypass grafting: insights from serial cardiac MRI.
MedLine Citation:
PMID:  21378388     Owner:  NLM     Status:  Publisher    
Objectives To examine, using cardiac magnetic resonance (CMR), the utility of cardiac biomarkers for the determination of myocyte necrosis and function after coronary artery bypass grafting (CABG), and to test the recently updated guidelines for the diagnosis of postoperative myocardial infarction (type V MI). Methods and results Forty patients included in a single-centre randomised trial of two surgical techniques for performing CABG underwent serial assessment with CMR biochemical markers. Cine and delayed enhancement CMR (DE-CMR) for assessment of left ventricular (LV) function and irreversible myocyte necrosis was performed and levels of troponin I (TnI) and creatine kinase-MB isoform (CK-MB) were determined. The area under the curve for TnI strongly correlated with the mass of new myocyte necrosis as assessed by DE-CMR (r=0.83, p<0.001), compared with CK-MB (r=0.39, p=0.06). Furthermore, routine assessment of TnI alone at 24&emsp14;h (>6.6&emsp14;μg/l) predicted type V MI on DE-CMR with a sensitivity of 88% and specificity of 97%, whereas CK-MB predicted type V MI with a sensitivity of 75% and specificity of 87%. Conclusions Biomarkers alone (TnI), at an appropriate threshold appear robust for the detection of type V MI, independently of supplementary evidence, as suggested by the ESC/ACCF/AHA/WHF criteria. Clinical trial registration information The study is listed on the Current Controlled Trials Registry: ISRCTN41388968. URL:
Tammy J Pegg; Zoe Maunsell; Theodoros D Karamitsos; Richard P Taylor; Tim James; Jane M Francis; David P Taggart; Harvey White; Stefan Neubauer; Joseph B Selvanayagam
Related Documents :
10544968 - Antiarrhythmic effect of magnesium sulfate against occlusion-induced arrhythmias and re...
7685888 - Potential hazards of fixed gain sensing and arrhythmia reconfirmation for implantable c...
1719848 - The effects of halothane on ventricular tachycardia in intact dogs.
6624658 - Value of left ventricular ejection fraction in extensive anterior infarction to predict...
10235688 - Cardiotoxicity of the antiproliferative compound fluorouracil.
18675118 - Role of sildenafil in acute posttransplant right ventricular dysfunction: successful ex...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-4
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  -     ISSN:  1468-201X     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
(OCMR), Oxford, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Allowing for never and episodic consumers when correcting for error in food record measurements of d...
Next Document:  Effects of intensive glucose control on platelet reactivity in patients with acute coronary syndrome...