| Utility-based outcomes made easy: the number needed per quality-adjusted life year gained. An observational cohort study of tumor necrosis factor blockade in inflammatory arthritis from Southern Sweden. | |
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MedLine Citation:
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PMID: 20506121 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To introduce a novel, simple, utility-based outcome measure, the number needed per quality-adjusted life year (QALY) gained (NNQ), and to apply it in clinical practice in anti-tumor necrosis factor (anti-TNF)-treated patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and spondylarthritis (SpA). METHODS: The NNQ is the number of patients one has to treat in order to gain 1 QALY. It is calculated as the inverted value of the utility gain (area under the curve) over 1 year in a cohort subjected to an intervention. EuroQol Index utility data from the South Swedish Arthritis Treatment register were used. RESULTS: Patients with RA (n = 1,001), PsA (n = 241), and SpA (n = 255) were eligible for the study. First, second, and third treatment courses were studied. For RA, NNQ was 4.5, 6.4, and 5.2 for first, second, and third courses, respectively. For PsA and SpA, NNQ was 4.2-4.5, irrespective of treatment order. Treatment groups with <50 patients were not analyzed. During the study period 2002-2007, there were no secular trends of utility gains. CONCLUSION: The NNQ is an easily derived and understandable utility-based outcome measure that may be useful for stakeholders and decision makers as well as for clinicians. It was readily applied in this study of TNF blockade across 3 arthritis diagnoses. NNQ varied little over diagnoses and treatment course order, with a possible exception in second treatment course in RA. |
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Authors:
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Anders Gülfe; Lars Erik Kristensen; Tore Saxne; Lennart T H Jacobsson; Ingemar F Petersson; Pierre Geborek |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Arthritis care & research Volume: 62 ISSN: 2151-4658 ISO Abbreviation: Arthritis Care Res (Hoboken) Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-08 Completed Date: 2010-10-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101518086 Medline TA: Arthritis Care Res (Hoboken) Country: United States |
Other Details:
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Languages: eng Pagination: 1399-406 Citation Subset: IM |
Affiliation:
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Lund University, Sweden. anders.gulfe@med.lu.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antirheumatic Agents / pharmacology, therapeutic use Arthritis, Psoriatic / drug therapy*, epidemiology, pathology Arthritis, Rheumatoid / drug therapy*, epidemiology, pathology Biological Products / therapeutic use Cohort Studies Female Humans Male Middle Aged Outcome Assessment (Health Care)* / standards Quality-Adjusted Life Years* Spondylarthritis / drug therapy*, epidemiology, pathology Sweden / epidemiology Treatment Outcome Tumor Necrosis Factor-alpha / antagonists & inhibitors*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Antirheumatic Agents; 0/Biological Products; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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