| Utility of XY-amelogenin gene primers for detection of sex chromosomes. | |
MedLine Citation:
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PMID: 9604546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The utility of polymerase chain reaction (PCR) amplification of amelogenin gene as a reliable and rapid means of determination of sex chromosomes was tested in 20 patients of X-linked disorders (Duchenne muscular dystrophy, haemophilia and Wiscott-Aldrich and Hunter's syndromes), 12 of intersex (testicular feminization syndrome, male pseudohermaphrodites, true hermaphrodites) and 21 of congenital adrenal hyperplasia. Of these, 26 (49%) cases were for prenatal diagnosis of X-linked diseases and congenital adrenal hyperplasia (CAH). The presence of X and Y chromosomes was determined within 24 h of receiving the samples. The results were in conformity with cytogenetic studies in all instances. The analysis of amelogenin gene proved helpful in the diagnosis and management of these patients. |
Authors:
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M R Chowdhury; R Mathur; I C Verma |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Indian journal of medical research Volume: 107 ISSN: 0971-5916 ISO Abbreviation: Indian J. Med. Res. Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-06-11 Completed Date: 1998-06-11 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 0374701 Medline TA: Indian J Med Res Country: INDIA |
Other Details:
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Languages: eng Pagination: 182-6 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, All India Institute of Medical Sciences, New Delhi. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Amelogenin Child Child, Preschool Dental Enamel Proteins / genetics* Humans Polymerase Chain Reaction* Prenatal Diagnosis Sex Chromosome Aberrations / diagnosis Sex Chromosomes* |
| Chemical | |
Reg. No./Substance:
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0/Amelogenin; 0/Dental Enamel Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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