Document Detail

Utility of Tc-99m mebrofenin scintigraphy in the assessment of infantile jaundice.
MedLine Citation:
PMID:  7720308     Owner:  NLM     Status:  MEDLINE    
Technetium-99m mebrofenin hepatobillary excretory patterns were assessed in 36 infants with hyperbilirubinemia. Phenobarbital was administered to 22 patients before imaging. Final diagnoses included: intrahepatic cholestasis (14 patients), neonatal hepatitis (nine patients), biliary atresia (eight patients), alpha-1-antitrypsin deficiency (two patients), Alagille's syndrome (two patients), and cystic fibrosis (one patient). No patient with biliary atresia showed bowel activity by 24 hours. Of the 28 infants without biliary atresia, 23 (82%) had bowel activity visualized by 6-8 hours and 26 (90%) had bowel activity by 24 hours. Two had no bowel activity at 24 hours: one had cystic fibrosis and one had neonatal hepatitis. Of the 26 patients with bowel visualization, the time to visualize bowel did not differ between patient groups with and without phenobarbital induction. All of the patients with hepatitis, including those with marked dysfunction, showed good hepatic uptake. Mebrofenin scintigraphy is an important imaging technique in the diagnostic evaluation of infants with hyperbilrubinemia. In addition to biliary atresia, intrahepatic cholestasis due to cystic fibrosis and severe neonatal hepatitis may also cause bowel nonvisualization up to 24 hours. The results of this study suggest phenobarbital induction may not be needed when Tc-99m mebrofenin scintigraphy is used for the assessment of infantile jaundice.
S Ben-Haim; J E Seabold; S C Kao; J Johnson; D Tran; B P Brown
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  20     ISSN:  0363-9762     ISO Abbreviation:  Clin Nucl Med     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-05-23     Completed Date:  1995-05-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  153-63     Citation Subset:  IM    
Department of Radiology, University of Iowa College of Medicine, Iowa City, USA.
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MeSH Terms
Biliary Atresia / complications,  radionuclide imaging
Cholestasis, Intrahepatic / radionuclide imaging
Hepatitis / complications,  radionuclide imaging
Imino Acids / diagnostic use*
Infant, Newborn
Jaundice, Neonatal / etiology,  radionuclide imaging*,  ultrasonography
Liver / radionuclide imaging*,  ultrasonography
Organotechnetium Compounds / diagnostic use*
Phenobarbital / diagnostic use
Time Factors
Reg. No./Substance:
0/Imino Acids; 0/Organotechnetium Compounds; 0/technetium Tc 99m mebrofenin; 50-06-6/Phenobarbital

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