| Utility of Tc-99m mebrofenin scintigraphy in the assessment of infantile jaundice. | |
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MedLine Citation:
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PMID: 7720308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Technetium-99m mebrofenin hepatobillary excretory patterns were assessed in 36 infants with hyperbilirubinemia. Phenobarbital was administered to 22 patients before imaging. Final diagnoses included: intrahepatic cholestasis (14 patients), neonatal hepatitis (nine patients), biliary atresia (eight patients), alpha-1-antitrypsin deficiency (two patients), Alagille's syndrome (two patients), and cystic fibrosis (one patient). No patient with biliary atresia showed bowel activity by 24 hours. Of the 28 infants without biliary atresia, 23 (82%) had bowel activity visualized by 6-8 hours and 26 (90%) had bowel activity by 24 hours. Two had no bowel activity at 24 hours: one had cystic fibrosis and one had neonatal hepatitis. Of the 26 patients with bowel visualization, the time to visualize bowel did not differ between patient groups with and without phenobarbital induction. All of the patients with hepatitis, including those with marked dysfunction, showed good hepatic uptake. Mebrofenin scintigraphy is an important imaging technique in the diagnostic evaluation of infants with hyperbilrubinemia. In addition to biliary atresia, intrahepatic cholestasis due to cystic fibrosis and severe neonatal hepatitis may also cause bowel nonvisualization up to 24 hours. The results of this study suggest phenobarbital induction may not be needed when Tc-99m mebrofenin scintigraphy is used for the assessment of infantile jaundice. |
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Authors:
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S Ben-Haim; J E Seabold; S C Kao; J Johnson; D Tran; B P Brown |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 20 ISSN: 0363-9762 ISO Abbreviation: Clin Nucl Med Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-05-23 Completed Date: 1995-05-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 153-63 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Iowa College of Medicine, Iowa City, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biliary Atresia
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complications,
radionuclide imaging Cholestasis, Intrahepatic / radionuclide imaging Female Hepatitis / complications, radionuclide imaging Humans Imino Acids / diagnostic use* Infant Infant, Newborn Jaundice, Neonatal / etiology, radionuclide imaging*, ultrasonography Liver / radionuclide imaging*, ultrasonography Male Organotechnetium Compounds / diagnostic use* Phenobarbital / diagnostic use Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Imino Acids; 0/Organotechnetium Compounds; 0/technetium Tc 99m mebrofenin; 50-06-6/Phenobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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