Document Detail


Utility of salivary melatonin measurements in the assessment of the pineal physiology in newborn infants.
MedLine Citation:
PMID:  20433823     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SUBJECTS: The aim of this study was to assess whether salivary melatonin could be used as a reliable alternative to serum melatonin to study the pineal physiology in newborn infants. DESIGN AND METHODS: The 95 newborn infants were allocated to four groups according to the time of sampling (09-11am, 03-05pm, 09-11pm, and 03-05am). RESULTS: The median melatonin levels in serum and saliva were not significantly different between groups: median (interquartile range), 18.4pg/mL (13.9-26.0pg/mL) and 10.6pg/mL (7.5-14.9pg/mL); 13.3pg/mL (11.5-19.0pg/mL) and 9.1pg/mL (7.8-14.2pg/mL); 16.0pg/mL (12.4-18.7pg/mL) and 12.3pg/mL (8.2-16.8pg/mL); 13.0pg/mL (8.8-27.4pg/mL) and 11.2pg/mL (7.7-16.6pg/mL) for groups 1, 2, 3, and 4, respectively (p>0.05). The results revealed a highly significant correlation between the serum and salivary melatonin levels (Pearson's correlation coefficient, r=0.763; P<0.001). CONCLUSION: Melatonin levels in saliva reflect those in serum at any time of the day and like serum melatonin levels do not increase at night.
Authors:
Soyhan Bagci; Andreas Mueller; Jochen Reinsberg; Axel Heep; Peter Bartmann; Axel R Franz
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Publication Detail:
Type:  Journal Article     Date:  2010-04-28
Journal Detail:
Title:  Clinical biochemistry     Volume:  43     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  868-72     Citation Subset:  IM    
Copyright Information:
Copyright 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Neonatology, Children's Hospital, University of Bonn, Adenauerallee 119, D-53113 Bonn, Germany. soyhan.bagci@ukb.uni-bonn.de
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MeSH Terms
Descriptor/Qualifier:
Enzyme-Linked Immunosorbent Assay
Humans
Infant, Newborn
Linear Models
Melatonin / blood*
Pineal Gland / metabolism*
Reproducibility of Results
Saliva / chemistry*,  metabolism
Sensitivity and Specificity
Xerostomia / blood,  metabolism
Chemical
Reg. No./Substance:
73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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