| Utility of salivary melatonin measurements in the assessment of the pineal physiology in newborn infants. | |
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MedLine Citation:
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PMID: 20433823 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SUBJECTS: The aim of this study was to assess whether salivary melatonin could be used as a reliable alternative to serum melatonin to study the pineal physiology in newborn infants. DESIGN AND METHODS: The 95 newborn infants were allocated to four groups according to the time of sampling (09-11am, 03-05pm, 09-11pm, and 03-05am). RESULTS: The median melatonin levels in serum and saliva were not significantly different between groups: median (interquartile range), 18.4pg/mL (13.9-26.0pg/mL) and 10.6pg/mL (7.5-14.9pg/mL); 13.3pg/mL (11.5-19.0pg/mL) and 9.1pg/mL (7.8-14.2pg/mL); 16.0pg/mL (12.4-18.7pg/mL) and 12.3pg/mL (8.2-16.8pg/mL); 13.0pg/mL (8.8-27.4pg/mL) and 11.2pg/mL (7.7-16.6pg/mL) for groups 1, 2, 3, and 4, respectively (p>0.05). The results revealed a highly significant correlation between the serum and salivary melatonin levels (Pearson's correlation coefficient, r=0.763; P<0.001). CONCLUSION: Melatonin levels in saliva reflect those in serum at any time of the day and like serum melatonin levels do not increase at night. |
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Authors:
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Soyhan Bagci; Andreas Mueller; Jochen Reinsberg; Axel Heep; Peter Bartmann; Axel R Franz |
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Publication Detail:
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Type: Journal Article Date: 2010-04-28 |
Journal Detail:
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Title: Clinical biochemistry Volume: 43 ISSN: 1873-2933 ISO Abbreviation: Clin. Biochem. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-11-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 868-72 Citation Subset: IM |
Copyright Information:
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Copyright 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neonatology, Children's Hospital, University of Bonn, Adenauerallee 119, D-53113 Bonn, Germany. soyhan.bagci@ukb.uni-bonn.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Enzyme-Linked Immunosorbent Assay Humans Infant, Newborn Linear Models Melatonin / blood* Pineal Gland / metabolism* Reproducibility of Results Saliva / chemistry*, metabolism Sensitivity and Specificity Xerostomia / blood, metabolism |
| Chemical | |
Reg. No./Substance:
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73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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