Document Detail

Utility of NT-pro-BNP in patients undergoing transapical aortic valve replacement.
MedLine Citation:
PMID:  20140438     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Transapical aortic valve replacement (TAVR) is increasingly being applied in conventionally inoperable patients with aortic stenosis. The utility of the cardiac marker NT-pro-BNP has yet not been assessed in this setting. METHODS: NT-pro-BNP was assessed preoperatively, postoperatively (day 1, 3, 5 and 8) and 2 months after the intervention in 31 consecutive patients (13 men, 18 women; median age 84) undergoing TAVR and the association with baseline characteristics and outcome was analysed. RESULTS: Baseline NT-pro-BNP was associated with baseline creatinine, left-ventricular mass index and NYHA class and predicted regression of LV-mass after 2 months. There was no correlation of NT-pro-BNP with measures of the aortic valve function before or after replacement. The increase of NT-pro-BNP 3 days after TAVR was inversely associated with a functional improvement of >or=1 NYHA class at 2 months. Baseline NT-pro-BNP was not associated with 2-month mortality and major adverse events (death/neurological deficit), whereas the postoperative increase of NT-pro-BNP after TAVR showed a slightly significant inverse and the EuroSCORE a significant correlation. CONCLUSIONS: In multimorbid patients undergoing TAVR, NT-pro-BNP independently predicted regression of LV-mass after 2 months and early decrease of NT-pro-BNP postoperatively indicated improvement of functional capacity at 2 months. There was no association of NT-pro-BNP with 2-month mortality.
Roman Pfister; Thorsten Wahlers; Frank M Baer; Max Scherner; Justus Strauch; Erland Erdmann
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Publication Detail:
Type:  Journal Article     Date:  2010-02-06
Journal Detail:
Title:  Clinical research in cardiology : official journal of the German Cardiac Society     Volume:  99     ISSN:  1861-0692     ISO Abbreviation:  Clin Res Cardiol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264123     Medline TA:  Clin Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  301-7     Citation Subset:  IM    
Department of Internal Medicine III, Herzzentrum, University of Cologne, Kerpenerstr. 62, 50937, Cologne, Germany.
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MeSH Terms
Aged, 80 and over
Aortic Valve Stenosis / blood,  diagnosis*,  surgery*
Biological Markers / blood
Heart Valve Prosthesis*
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Reproducibility of Results
Risk Assessment
Risk Factors
Sensitivity and Specificity
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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