| Utility of PET/neck MRI digital fusion images in the management of recurrent or persistent thyroid cancer. | |
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MedLine Citation:
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PMID: 18279011 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Approximately 30% of thyroid cancer patients present with reappearing disease within 40 years of initial diagnosis. Hence, sensitive postsurgical monitoring techniques are imperative to successful long-term care. The objective of this study was to assess the added clinical utility of a combined positron emission tomography/magnetic resonance imaging (PET/MRI) of the neck in conjunction with standard imaging in the detection of recurrent thyroid carcinoma. We define standard imaging as a neck sonogram, 131I scan, computed tomography, and MRI. METHODS: This study included 34 patients treated for thyroid cancer at Washington Hospital Center. All patients had previously undergone near-total or total thyroidectomy, standard follow-up imaging studies, and laboratory studies. Twenty-nine of thirty-four patients had received at least one 131I treatment prior to the study. Each patient received a PET and MRI scan, and these images were subsequently digitally fused. RESULTS: Individually and blinded, four endocrinologists retrospectively reviewed all information in patient charts prior to PET and PET/MRI coregistration. A clinical assessment and treatment plan were devised with these data. Following the initial assessment, the endocrinologists were provided results from the PET and PET/MRI fusion studies and asked to make a revised assessment and treatment plan. For each patient, the physicians categorized PET/MRI fusion results as providing new information that altered the initial treatment plan, providing new information that confirmed the initial treatment plan, or providing no additional information. On average, PET/MRI coregistration provided additional information that altered the treatment plan in 46% of the cases, provided additional information that confirmed the treatment plan in 36% of cases, and did not provide any additional information in 18% of cases. CONCLUSION: The combination of structural and functional data that PET/neck MRI fusion offers provided further information in an overwhelming majority of thyroid cancer patients in this study. Thus PET/MRI can be a useful tool in surgical planning, radioactive iodine therapy decisions, and determining the level of follow-up necessary for each patient. |
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Authors:
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Laura Seiboth; Douglas Van Nostrand; Leonard Wartofsky; Yasser Ousman; Jacqueline Jonklaas; Calvin Butler; Frank Atkins; Kenneth Burman |
Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Thyroid : official journal of the American Thyroid Association Volume: 18 ISSN: 1050-7256 ISO Abbreviation: Thyroid Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-18 Completed Date: 2008-04-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9104317 Medline TA: Thyroid Country: United States |
Other Details:
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Languages: eng Pagination: 103-11 Citation Subset: IM |
Affiliation:
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Endocrine Medicine Section, Washington Hospital Center, Georgetown University Medical Center, Washington, DC 20010, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Carcinoma, Papillary / pathology*, radionuclide imaging, therapy Female Fluorodeoxyglucose F18 / diagnostic use Humans Image Interpretation, Computer-Assisted Iodine Radioisotopes / diagnostic use, therapeutic use Magnetic Resonance Imaging* Male Middle Aged Neoplasm Recurrence, Local* Patient Selection* Positron-Emission Tomography* Predictive Value of Tests Radiopharmaceuticals / diagnostic use Retrospective Studies Signal Processing, Computer-Assisted* Thyroid Neoplasms / pathology*, radionuclide imaging, therapy Thyroidectomy Tomography, X-Ray Computed Treatment Outcome Ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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