| Utility of cerebrospinal fluid cytology in newly diagnosed childhood ependymoma. | |
| | |
MedLine Citation:
|
PMID: 20463607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The role of cytology of cerebrospinal fluid (CSF) has not been established in pediatric ependymoma. Thirty-two children with metastatic ependymoma were analyzed: 11 patients had only positive CSF cytology, 6 had only positive magnetic resonance imaging (MRI) findings, and 15 had both CSF cytology and MRI positive. Twenty-two patients relapsed. Five-year event-free survival was 27.3%+/-13.4% for children with only CSF positive (M1) versus 26.1%+/-10.2% for patients with positive spine MRI positive (with or without CSF positive, M3) (P=0.87). In conclusion, 34% of the patients with metastatic ependymoma were identified based on CSF cytology only and their outcome was comparable to patients with macroscopic disease. CSF cytology is a useful tool to stage newly diagnosed patients with ependymoma. |
| | |
Authors:
|
Lucas Moreno; Ian F Pollack; Patricia K Duffner; J Russell Geyer; Jacques Grill; Maura Massimino; Jonathan L Finlay; Stergios Zacharoulis |
Related Documents
:
|
23241607 - Moderate elevations of high-sensitivity cardiac troponin i and b-type natriuretic pepti... 18705467 - Observation of spontaneous cerebrospinal fluid rhinorrhoea to body mass index: a prelim... 7751857 - Rapid diagnosis of tuberculous meningitis by polymerase chain reaction assay of cerebro... 1295027 - Computer-assisted stereotactic third ventriculostomy in the management of noncommunicat... 8546267 - Increased frequency of bronchial hyperresponsiveness in patients with inflammatory bowe... 12169747 - Transbronchial needle aspiration in the diagnosis of intrathoracic lymphadenopathy. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of pediatric hematology/oncology Volume: 32 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-06 Completed Date: 2010-08-20 Revised Date: 2013-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
|
Languages: eng Pagination: 515-8 Citation Subset: IM |
Affiliation:
|
Department of Paediatrics, The Royal Marsden NHS Foundation Trust, Sutton, UK. lucasmorenomr@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Brain Neoplasms
/
cerebrospinal fluid*,
diagnosis*,
mortality Child Child, Preschool Disease-Free Survival Ependymoma / cerebrospinal fluid*, diagnosis*, mortality Female Humans Kaplan-Meier Estimate Male Neoplasm Staging Proportional Hazards Models |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pattern of relapse in childhood ALL: challenges and lessons from a uniform treatment protocol.
Next Document: Sorafenib plus valproic acid for infant spinal glioblastoma.