Document Detail

Utility of B-type natriuretic peptide in predicting perioperative cardiac events in patients undergoing major non-cardiac surgery.
MedLine Citation:
PMID:  17573389     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: B-type natriuretic peptide (BNP) levels predict cardiovascular risk in several settings. We hypothesized that they would identify individuals at increased risk of early cardiac complications after major non-cardiac surgery. The current study tests this hypothesis. METHODS: Two hundred and four patients undergoing major non-cardiac surgery were studied. The primary end-point was the development of acute myocardial injury [defined as cardiac troponin I (cTnI) level > 0.32 ng ml(-1)] or death in the 3 days after surgery. RESULTS: Preoperative BNP levels were raised in patients who died or suffered perioperative myocardial injury (median 52.2 vs 22.2 pg ml(-1), P = 0.01) and BNP predicted this outcome with an area under the receiver operating characteristic curve of 0.72 [95% confidence interval (CI) 0.59-0.86, P = 0.01]. A preoperative BNP value > 40 pg ml(-1) was associated with an increased risk of death or perioperative myocardial injury [odds ratio (OR) 6.8, 95% CI 1.8-25.9, P = 0.003], and remained independently predictive after correction for the Revised Cardiac Risk Index. Preoperative BNP levels were higher in patients who exhibited new onset atrial fibrillation or ST/T-wave changes on their postoperative ECG (median 50.5 vs 22.5 pg litre(-1), P = 0.01). They were also higher in patients who had either elevation of cTnI > 0.32 ng ml(-1) or postoperative ECG abnormalities (median 50.4 vs 21.5 pg ml(-1), P < 0.001). CONCLUSIONS: In the setting of major non-cardiac surgery, preoperative BNP levels are higher in patients who experience perioperative death and myocardial injury. Larger studies are required to confirm these data and to clarify what BNP levels may add to existing methods of risk stratification.
B H Cuthbertson; A R Amiri; B L Croal; S Rajagopalan; O Alozairi; J Brittenden; G S Hillis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-15
Journal Detail:
Title:  British journal of anaesthesia     Volume:  99     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-08-21     Revised Date:  2007-11-19    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  170-6     Citation Subset:  IM    
Health Services Research Unit, University of Aberdeen and Aberdeen Royal Infirmary, Aberdeen, UK.
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MeSH Terms
Aged, 80 and over
Biological Markers / blood
Epidemiologic Methods
Length of Stay
Middle Aged
Myocardial Infarction / blood*
Natriuretic Peptide, Brain / blood*
Postoperative Complications / blood*
Preoperative Care / methods*
Troponin I / blood
Reg. No./Substance:
0/Biological Markers; 0/Troponin I; 114471-18-0/Natriuretic Peptide, Brain
Comment In:
Br J Anaesth. 2007 Nov;99(5):746-7; author reply 747   [PMID:  17933803 ]
Br J Anaesth. 2007 Aug;99(2):151-4   [PMID:  17616564 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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