Document Detail


Uteroplacental circulatory disturbance mediated by prostaglandin f2alpha in rats exposed to microwaves. hiro-n@po.incl.ne.jp.
MedLine Citation:
PMID:  10838124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To clarify the effects of microwaves on pregnancy, uterine or uteroplacental blood flow and endocrine and biochemical mediators, including corticosterone, estradiol, prostaglandin E(2) (PGE(2)), and prostaglandin F(2)alpha (PGF(2)alpha), were measured in rats exposed to continuous-wave (CW) microwave at 2 mW/cm(2) incident power density at 2450 MHz for 90 min. Colonic temperature in virgin and pregnant rats was not significantly altered by microwave treatment. Microwaves decreased uteroplacental blood flow and increased progesterone and PGF(2)alpha in pregnant, but not in virgin rats. Intraperitoneal (i.p.) administration of angiotensin II, a uteroplacental vasodilator, before microwave exposure prevented the reduction in uteroplacental blood flow and the increased progesterone and PGF(2)alpha in pregnant rats. Increased corticosterone and decreased estradiol during microwave exposure were observed independent of pregnancy and pretreatment with angiotensin II. These results suggest that microwaves (CW, 2 mW/cm(2), 2450 MHz) produce uteroplacental circulatory disturbances and ovarian and placental dysfunction during pregnancy, probably through nonthermal actions. The uteroplacental disturbances appear to be due to actions of PGF(2)alpha and may pose some risk for pregnancy.
Authors:
H Nakamura; H Nagase; K Ogino; K Hatta; I Matsuzaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  14     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:    2000 May-Jun
Date Detail:
Created Date:  2000-08-01     Completed Date:  2000-08-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  235-40     Citation Subset:  IM    
Affiliation:
Department of Public Health, Kanazawa University School of Medicine, Takaramachi 13-1, 920-8640, Kanazawa, Japan.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / pharmacology
Animals
Body Temperature / radiation effects
Corticosterone / blood
Dinoprost / blood*
Dinoprostone / blood
Estradiol / blood
Female
Microwaves / adverse effects*
Placental Circulation / drug effects,  radiation effects*
Pregnancy
Pregnancy, Animal / blood,  radiation effects*
Progesterone / blood
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
11128-99-7/Angiotensin II; 363-24-6/Dinoprostone; 50-22-6/Corticosterone; 50-28-2/Estradiol; 551-11-1/Dinoprost; 57-83-0/Progesterone

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