Document Detail


Uteroplacental O2 uptake: continuous measurements during uterine quiescence and contractions.
MedLine Citation:
PMID:  3717383     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the constancy of uteroplacental O2 uptake (VO2) during uterine quiescence and both spontaneous and oxytocin-induced uterine contractions, we have developed a method to measure VO2 continuously and reproducibly. In seven ewes during uterine quiescence, total uterine blood flow (Qut) averaged 200 ml X min-1 X kg uterine contents-1, with intra-animal SD of 18 min X min-1 X kg-1 and interanimal SD of 86 ml X min-1 X kg-1. Uterine arteriovenous O2 content difference averaged 4.2 +/- 0.5 ml X dl-1. VO2 averaged 8.2 +/- 1.2 ml X min-1 X kg-1, with interanimal SD of 3.6 ml X min-1 X kg-1. During 21 spontaneous prelabor contractions, VO2 decreased 3.8% to 8.7 +/- 0.3 ml X min-1 X kg-1 (NS) during the contraction and subsequently increased 12.3% to 10.1 +/- 0.3 ml X min-1 X kg-1 (P less than 0.05) near the end of the contraction. With oxytocin-induced contractions, VO2 fell 10% to 6.4 +/- 0.2 ml X min-1 X kg-1 at the contraction onset (P less than 0.05) but by the end of the contraction had increased 6.1% to 7.6 +/- 0.2 ml X min-1 X kg-1 (NS). In conclusion, uteroplacental VO2 was measured continuously and reproducibly using relatively straightforward methodology; uteroplacental blood flow, arteriovenous O2 content difference, and uteroplacental O2 uptake were normally distributed with coefficients of variation less than 15%; and during both spontaneous and oxytocin-induced uterine contractions Qut decreased significantly, while VO2 initially decreased moderately and then showed an overshoot, during the contraction.
Authors:
L D Longo; P S Dale; R D Gilbert
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  250     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-24     Completed Date:  1986-07-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1099-107     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries
Evaluation Studies as Topic
Female
Monitoring, Physiologic / instrumentation,  methods*
Oxygen / blood
Oxygen Consumption*
Oxytocin / pharmacology
Placenta / metabolism*
Pregnancy
Regional Blood Flow
Uterine Contraction*
Uterus / blood supply,  drug effects,  metabolism*
Veins
Grant Support
ID/Acronym/Agency:
HD-03807/HD/NICHD NIH HHS; HD-13949/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
50-56-6/Oxytocin; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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