Document Detail

Uteroglobin in the rabbit. II. Intracellular localization in the uterus after hormone treatment.
MedLine Citation:
PMID:  782714     Owner:  NLM     Status:  MEDLINE    
Rabbit uterine uteroglobin (UGL) was studied by electrophoretic and immunological methods following normal copulation, after ovariectomy and progesterone treatment, 17beta-oestradiol and combined progesterone treatment, 17 beta-oestradiol treatment alone and after HCG-induced pseudopregnancy. Electrophoretic studies show the amount of ULG in uterine secretions, the immunological investigations indicate the intracellular localization of ULG and the distribution of ULG-positive cells in the endometrium. No obvious differences were found between the uteri 7 days after injection with chorion-gonadotropin and those 7 days following normal copulation. No differences could be domonstrated between the uteri of animals 35 days following ovariectomy and subsequent progesterone treatment on Days 31-33 and those of normal 7 d. post coitum (p.c.) animals. Uteri from animals treated with progesterone on Days 2-5 p.c. contained more ULG-positive cells than controls. 17beta-oestradiol treatment with and without subsequent progesterone treatment resulted, in both gravid and ovariectomized animals, in the formation of a tall columnar endometrial epithelium. Treatment with 17 beta-oestradiol on Days 1 and 2 p.c. led to a decrease in the number of UGL-positive cells at 7 days p.c. Even after ovariectomy with 17 beta-oestradiol substitution, UGL-positive cells were still present in the endometrium. However a secretion of any magnitude could not be detected. The importance of differentiation between synthesis and secretion (= release) as distinct phases of the glandular response is especially emphasised by the latter findings.
C Kirchner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell and tissue research     Volume:  170     ISSN:  0302-766X     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  1976 Jul 
Date Detail:
Created Date:  1976-10-20     Completed Date:  1976-10-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  425-34     Citation Subset:  IM    
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MeSH Terms
Chorionic Gonadotropin
Endometrium / analysis
Estradiol / pharmacology*
Glycoproteins / analysis*
Immunologic Techniques
Progesterone / pharmacology*
Time Factors
Uteroglobin / analysis*
Uterus / analysis*
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Glycoproteins; 50-28-2/Estradiol; 57-83-0/Progesterone; 9060-09-7/Uteroglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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